{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T05:04:27Z","timestamp":1761541467709,"version":"3.40.5"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,2,20]],"date-time":"2019-02-20T00:00:00Z","timestamp":1550620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We performed an analysis of the National Cancer Database (NCDB) to evaluate overall survival (OS) in patients with base of tongue (BOT) cancer treated with external beam radiation therapy (EBRT) combined with brachytherapy (BT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The tongue NCDB Participant User File was used to obtain demographic and clinical patient data. The Kaplan\u2013Meier method was used to determine OS. Significance was determined using univariable and multivariable Cox proportional hazards models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At 3 years, OS was 69.6%, 77.1%, and 63.7% for patients treated with EBRT (<jats:italic>n<\/jats:italic> =\u200927\u2009954), EBRT\u2009+\u2009BT (<jats:italic>n<\/jats:italic> =\u2009209), or BT alone (<jats:italic>n<\/jats:italic> =\u2009154), respectively (<jats:italic>P<\/jats:italic> =\u2009.01). On multivariable analysis, the instantaneous hazard of death for patients receiving EBRT\u2009+\u2009BT was 25% (Hazard ratio [HR]\u2009= 0.75, 95% CI: 0.58\u20100.98) lower than patients receiving only EBRT (<jats:italic>P<\/jats:italic> =\u2009.03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The addition of BT to EBRT in BOT cancer has an OS benefit.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.25497","type":"journal-article","created":{"date-parts":[[2019,2,21]],"date-time":"2019-02-21T04:48:12Z","timestamp":1550724492000},"page":"1184-1192","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["National Cancer Database Analysis of the effect of brachytherapy on overall survival in patients with base of tongue cancer"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6028-3685","authenticated-orcid":false,"given":"Scott 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J.","family":"Hurst","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Henry Ford Hospital  Detroit Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,2,20]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21442"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brachy.2013.07.001"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brachy.2016.07.005"},{"issue":"4","key":"e_1_2_5_5_1","first-page":"404","article-title":"Modern head and neck brachytherapy: from radium towards intensity modulated interventional brachytherapy","volume":"6","author":"Kovacs G","year":"2015","journal-title":"J Contemp 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