{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T12:34:10Z","timestamp":1763037250837,"version":"3.40.5"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,12,11]],"date-time":"2018-12-11T00:00:00Z","timestamp":1544486400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Our objective was to determine the effect of post\u2010diagnosis aspirin use on survival in veterans with head and neck squamous cell carcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective cohort study of 584 veterans with head and neck squamous cell carcinoma treated at the Washington DC VA Medical Center between 1995 and 2015. Charts were queried for clinical\u2010pathologic data, aspirin prescriptions, and outcome. The Kaplan\u2013Meier method was used to determine overall survival (OS) and disease\u2010specific survival (DSS) among aspirin users and nonusers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 329 patients met inclusion criteria. Primary subsites included oropharynx (<jats:italic>n<\/jats:italic>\u2009=\u2009143), larynx (<jats:italic>n<\/jats:italic>\u2009=\u2009105), oral cavity (<jats:italic>n<\/jats:italic>\u2009=\u200962), and hypopharynx (<jats:italic>n<\/jats:italic>\u2009=\u200919). Eighty\u2010four patients were aspirin users (25.5%). Aspirin users demonstrated significantly better 3\u2010year OS and DSS (78.6% and 88.1%) compared to nonaspirin users (OS: 55.9% and DSS: 70.2%; <jats:italic>P<\/jats:italic>\u2009=\u2009.0003 and <jats:italic>P<\/jats:italic>\u2009=\u2009.0019, respectively). On multivariate analysis, aspirin use remained independently associated with improved survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Aspirin use following diagnosis and curative treatment of head and neck squamous cell carcinoma is associated with improved OS and DSS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.25518","type":"journal-article","created":{"date-parts":[[2018,12,11]],"date-time":"2018-12-11T13:53:40Z","timestamp":1544536420000},"page":"1220-1226","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Post\u2010diagnosis aspirin use and survival in veterans with head and neck cancer"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8609-9002","authenticated-orcid":false,"given":"Catherine J.","family":"Lumley","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery MedStar Georgetown University Hospital  Washington District of Columbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas M.","family":"Kaffenberger","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sameer","family":"Desale","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Biomedical informatics MedStar Health Research Institute  Washington District of Columbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eshetu","family":"Tefera","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Biomedical informatics MedStar Health Research Institute  Washington District of Columbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chihun Jim","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Georgetown University School of Medicine  Washington District of Columbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hind","family":"Rafei","sequence":"additional","affiliation":[{"name":"Department of Medicine George Washington University School of Medicine  Washington District of Columbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica H.","family":"Maxwell","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery MedStar Georgetown University Hospital  Washington District of Columbia"},{"name":"Department of Surgery Washington DC Veterans Affairs Medical Center  Washington District of 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