{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:02:35Z","timestamp":1773014555818,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,1,5]],"date-time":"2019-01-05T00:00:00Z","timestamp":1546646400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cetuximab is a common EGFR monoclonal antibody used with radiotherapy to treat head\u2010and\u2010neck cancer. Severe pulmonary toxicity, including interstitial lung disease (ILD), caused by cetuximab is rare.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We describe a patient who developed ILD and acute respiratory failure after concurrent chemoradiation with cetuximab for oropharyngeal squamous cell carcinoma, and review the literature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A patient developed acute respiratory failure 2\u2009months after starting concurrent chemoradiation with cetuximab and was hospitalized in intensive care after a procedure for progressive respiratory distress. Cultures and serology were negative for infection and radiologic findings were consistent with drug associated pneumonitits. Steroids were administered until the patient was stabilized. The patient fully recovered 1\u2009month after the onset of respiratory distress, although he died of recurrent disease 10 months after completing treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although severe pulmonary toxicity caused by EGFR inhibitors has been well described in the literature, ILD caused by cetuximab, an EGFR monoclonal antibody, is rare and not well\u2010documented. Given its life\u2010threatening effects, awareness of this potential side effect and early diagnosis is critical.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.25528","type":"journal-article","created":{"date-parts":[[2019,1,7]],"date-time":"2019-01-07T02:38:13Z","timestamp":1546828693000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Cetuximab\u2010associated pulmonary toxicity in concurrent chemoradiation for the treatment of a squamous cell carcinoma of the head and neck"],"prefix":"10.1002","volume":"41","author":[{"given":"John D.","family":"Mayfield","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology University of Florida College of Medicine  Gainesville Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine E.","family":"Mercado","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Florida College of Medicine  Gainesville Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederic J.","family":"Kaye","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology University of Florida College of Medicine  Gainesville Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6592-2810","authenticated-orcid":false,"given":"William M.","family":"Mendenhall","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Florida College of Medicine  Gainesville Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,1,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.10.010"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.06.7447"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2008.09.018"},{"key":"e_1_2_7_5_1","volume-title":"Cancer Staging Manual","author":"Edge S","year":"2011"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11523-011-0199-0"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11523-013-0295-4"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-017-4550-7"},{"issue":"2","key":"e_1_2_7_9_1","first-page":"3790","article-title":"Interstitial pneumonitis after using Cetuximab in cancer patients","volume":"9","author":"Zhang X","year":"2016","journal-title":"Int J Clin Exp Med"},{"issue":"12","key":"e_1_2_7_10_1","first-page":"2198","article-title":"Two cases of interstitial pneumonia caused by cetuximab plus mFOLFOX6 therapy in metastatic colorectal cancer patients","volume":"39","author":"Shioiri M","year":"2012","journal-title":"Gan To Kagaku Ryoho"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.5414\/CPP48425"},{"issue":"11","key":"e_1_2_7_12_1","first-page":"2193","article-title":"A case of recurrent colon cancer with angina pectoris and interstitial pneumonia during cetuximab therapy with death by carcinomatous lymphangiosis","volume":"37","author":"Shibahara H","year":"2010","journal-title":"Gan To Kagaku Ryoho"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-03-2012-5973"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyu128"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.3816\/CCC.2009.n.019"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13691-014-0191-5"},{"issue":"1","key":"e_1_2_7_17_1","first-page":"49","article-title":"Fatal interstitial pneumonia caused by panitumumab\u2010containing chemotherapy: a case report","volume":"39","author":"Yamane H","year":"2013","journal-title":"Kawasaki Med J"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40278-014-1821-6"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2011.11.009"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-015-0834-3"}],"container-title":["Head &amp; 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