{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T12:11:46Z","timestamp":1781179906901,"version":"3.54.1"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,1,10]],"date-time":"2019-01-10T00:00:00Z","timestamp":1547078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To investigate the management and outcomes of patients with lacrimal sac squamous cell carcinoma (SCC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study examined 69 lacrimal sac SCC cases treated at our hospital between 1992 and 2017. The potential risk factors for prognosis, a new staging method, treatment outcomes, and complications were investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The 5\u2010year overall survival (OS) and progression\u2010free survival (PFS) were 87.6 \u00b1 4.8% and 76.3 \u00b1 6.4%, respectively. Positive lymph node was associated with worse OS and PFS. We divided lacrimal sac SCC into four clinical stages, with significant differences in OS (<jats:italic>P<\/jats:italic> =\u2009.026) and PFS (<jats:italic>P<\/jats:italic> =\u2009.042) among each stage. Definitive radiotherapy was equivalent to surgery plus radiotherapy in 26.1% (18\/69) of cases, and the incidence of complications was not higher.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Lymph node status was a key factor in determining outcomes. Our staging method could effectively classify tumor stage and predict prognosis, which can contribute to optimizing treatment regimes. Radiotherapy played an important role in treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.25529","type":"journal-article","created":{"date-parts":[[2019,1,10]],"date-time":"2019-01-10T20:40:25Z","timestamp":1547152825000},"page":"974-981","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Clinical management and outcomes of lacrimal sac squamous cell carcinoma"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1669-2764","authenticated-orcid":false,"given":"Xinmao","family":"Song","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Eye, Ear, Nose &amp; Throat Hospital of FuDan University Fenyang Road 83  Shanghai 200031 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2307-0082","authenticated-orcid":false,"given":"Shengzi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Eye, Ear, Nose &amp; Throat Hospital of FuDan University Fenyang Road 83  Shanghai 200031 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of E.N.T. Eye, Ear, Nose &amp; Throat Hospital of FuDan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weifang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Eye, Ear, Nose &amp; Throat Hospital of FuDan University Fenyang Road 83  Shanghai 200031 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology Eye, Ear, Nose &amp; Throat Hospital of FuDan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Eye, Ear, Nose &amp; Throat Hospital of FuDan University Fenyang Road 83  Shanghai 200031 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Eye, Ear, Nose &amp; Throat Hospital of FuDan University Fenyang Road 83  Shanghai 200031 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Eye, Ear, Nose &amp; Throat Hospital of FuDan University Fenyang Road 83  Shanghai 200031 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Eye, Ear, Nose &amp; Throat Hospital of FuDan University Fenyang Road 83  Shanghai 200031 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjia","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of E.N.T. 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