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Survival analyses were incrementally adjusted for age, sex, marital status, income, education, stage, alcohol, and smoking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After adjusting for demographic, clinical, and behavioral confounders, higher baseline comorbidity was associated with reduced overall survival (mild comorbidity HR = 1.4, 95% CI = 1.1, 1.7; moderate comorbidity HR = 1.7, 95% CI = 1.3, 2.2; severe comorbidity HR = 2.8, 95% CI = 1.9, 4.; <jats:italic>P<\/jats:italic>\u2010trend&lt;.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings suggest that comorbidity is an independent prognosticator for overall survival in head and neck cancer. Comorbid illnesses should be considered in the assessment and treatment planning of people with head and neck cancer.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.25543","type":"journal-article","created":{"date-parts":[[2018,12,14]],"date-time":"2018-12-14T10:15:28Z","timestamp":1544782528000},"page":"1053-1062","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Association between comorbidity and survival in head and neck cancer: Results from Head and Neck 5000"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7539-2104","authenticated-orcid":false,"given":"Sarah","family":"Schimansky","sequence":"first","affiliation":[{"name":"National Institute of Health (NIHR) Bristol Biomedical Research Centre Nutrition Theme, University of Bristol  Bristol United 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