{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T06:26:51Z","timestamp":1768285611828,"version":"3.49.0"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,12,10]],"date-time":"2018-12-10T00:00:00Z","timestamp":1544400000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["(PI13\/00259)"],"award-info":[{"award-number":["(PI13\/00259)"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Focal adhesion kinase (FAK) and cortactin overexpression is frequently detected in a variety of cancers, and has been associated with poor clinical outcome. However, there are no data in cutaneous squamous cell carcinoma (cSCC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the relationship of FAK and cortactin expression with the clinicopathologic features and the impact on the prognosis of cSCC patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>FAK and cortactin expression was analyzed by immunohistochemistry on paraffin\u2010embedded tissue samples from 100 patients with cSCC, and correlated with the clinical data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>FAK overexpression was a significant risk factor for nodal metastasis with crude and adjusted ratios (HRs) of 2.04, (95% CI [1.08\u20103.86], [<jats:italic>P<\/jats:italic> = 0.029]) and 2.23 (95% CI [1.01\u20104.91], [<jats:italic>P<\/jats:italic> = 0.047]), respectively. Cortactin expression was not a significant risk factor for nodal metastasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These findings demonstrate that FAK overexpression is an independent predictor of nodal metastasis that might be helpful for risk stratification and management of patients with cSCC.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.25556","type":"journal-article","created":{"date-parts":[[2018,12,10]],"date-time":"2018-12-10T16:21:05Z","timestamp":1544458865000},"page":"1290-1296","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Correlation of focal adhesion kinase expression with nodal metastasis in patients with head and neck cutaneous squamous cell carcinoma"],"prefix":"10.1002","volume":"41","author":[{"given":"Pablo","family":"Mungu\u00eda\u2010Calzada","sequence":"first","affiliation":[{"name":"Service of Dermatology Hospital Universitario Central de Asturias, Universidad de Oviedo  Oviedo Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iv\u00e1n","family":"Fern\u00e1ndez\u2010Vega","sequence":"additional","affiliation":[{"name":"Service of Pathology Hospital Universitario Central de Asturias, Universidad de Oviedo  Oviedo Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo","family":"Mart\u00ednez\u2010Camblor","sequence":"additional","affiliation":[{"name":"Geisel School of Medicine at Dartmouth Dartmouth College  Hannover New Hampshire"},{"name":"Universidad Aut\u00f3noma de Chile  Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susana","family":"D\u00edaz\u2010Coto","sequence":"additional","affiliation":[{"name":"Universidad de Oviedo  Oviedo Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5891-9488","authenticated-orcid":false,"given":"Juana Mar\u00eda","family":"Garc\u00eda\u2010Pedrero","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Hospital Universitario Central de Asturias and Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias, Instituto Universitario de Oncolog\u00eda del Principado de Asturias University of Oviedo  Oviedo Spain"},{"name":"CIBERONC  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blanca","family":"Vivanco","sequence":"additional","affiliation":[{"name":"Service of Pathology Hospital Universitario Central de Asturias, Universidad de Oviedo  Oviedo Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina Galache","family":"Osuna","sequence":"additional","affiliation":[{"name":"Service of Dermatology Hospital Universitario Central de Asturias, Universidad de Oviedo  Oviedo Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Vazquez\u2010Lopez","sequence":"additional","affiliation":[{"name":"Service of Dermatology Hospital Universitario Central de Asturias, Universidad de Oviedo  Oviedo Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3063-0890","authenticated-orcid":false,"given":"Juan Pablo","family":"Rodrigo","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Hospital Universitario Central de Asturias and Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias, Instituto Universitario de Oncolog\u00eda del Principado de Asturias University of Oviedo  Oviedo Spain"},{"name":"CIBERONC  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5578-3522","authenticated-orcid":false,"given":"Jorge","family":"Santos\u2010Juanes","sequence":"additional","affiliation":[{"name":"Service of Dermatology Hospital Universitario Central de Asturias, Universidad de Oviedo  Oviedo Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,12,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2012.11.037"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2010.19"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.08.059"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2015.4994"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2017.06.025"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24765"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-3928"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2462"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1647"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6604286"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2017.01.003"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.26351"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2996"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-17-0418"},{"key":"e_1_2_7_16_1","first-page":"18","article-title":"Focal adhesion kinase: insight into molecular roles and functions in hepatocellular carcinoma","volume":"5","author":"Panera N","year":"2017","journal-title":"Int J Mol Sci"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12253-010-9310-6"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12676"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-14-1773"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-4490"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.4161\/cam.5.2.14773"},{"key":"e_1_2_7_22_1","volume-title":"American Joint Committee on Cancer Staging Manual","author":"Edge SB","year":"2010"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.01.015"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.11036"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.12740"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2012.63"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-10-0338"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1214\/aos\/1176350951"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1999.10474144"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10585-008-9154-6"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-17-1082"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.2741\/4236"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4123"},{"key":"e_1_2_7_34_1","first-page":"5","article-title":"FAK\u2010inhibition opens the door to checkpoint immunotherapy in pancreatic cancer","volume":"21","author":"Symeonides SN","year":"2017","journal-title":"J Immunother Cancer"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.09.001"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24584"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.093781"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.13652"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/1478-811X-12-17"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3792"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2015.1119356"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.25556","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hed.25556","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.25556","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T13:04:22Z","timestamp":1694351062000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.25556"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,10]]},"references-count":40,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["10.1002\/hed.25556"],"URL":"https:\/\/doi.org\/10.1002\/hed.25556","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,10]]},"assertion":[{"value":"2018-05-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}