{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T17:22:47Z","timestamp":1761844967358,"version":"3.40.5"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,12,11]],"date-time":"2018-12-11T00:00:00Z","timestamp":1544486400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>With most centers reporting excellent disease control following transoral surgery for human papillomavirus (HPV)\u2010related oropharyngeal cancer, data are still lacking regarding management and outcomes in patients who relapse. We describe the treatment outcomes after curative intent therapy for locoregional and distant relapse following transoral surgery for HPV\u2010related oropharyngeal squamous cell carcinoma (OPSCC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A single institution retrospective study in which patients were identified with curatively treated loco\u2010regional or single site distant relapse of HPV\u2010related OPSCC treated initially with transoral surgery (TOS) between 1996 and 2014.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 279 patients, 38 (13.6%) relapsed. 21 (7.5%) had local\u2010regional relapse and 18 were treated with curative intent. Three\u2010year overall survival for loco\u2010regional recurrence with curatively intended treatment was 75.3% (95% confidence intervals 54.3\u201096.0) with a median follow\u2010up 33 (range: 5\u201065) months. Among 4 patients with isolated distant metastasis who were treated with curative intent, all subsequently developed second relapse of disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Salvage curative treatment of isolated local\u2010regional relapse after TOS is associated with favorable prognosis and should be offered in appropriate candidates.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.25557","type":"journal-article","created":{"date-parts":[[2018,12,11]],"date-time":"2018-12-11T13:54:29Z","timestamp":1544536469000},"page":"1312-1319","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Outcomes of relapsed human papillomavirus\u2010related oropharyngeal squamous cell carcinoma treated with curative intent"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4118-7743","authenticated-orcid":false,"given":"Patrik","family":"Pipkorn","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Washington University  Saint Louis Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parul","family":"Sinha","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Washington University  Saint Louis Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorina","family":"Kallogjeri","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Washington University  Saint Louis Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas","family":"Adkins","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology Washington University  Saint Louis 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