{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T02:03:59Z","timestamp":1760061839927,"version":"3.40.5"},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,1,10]],"date-time":"2019-01-10T00:00:00Z","timestamp":1547078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The objective of this study was to determine survival outcomes in patients who underwent retreatment of recurrent cases of cutaneous melanoma of the head and neck (CMHN).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective review of all patients who were treated for primary clinical stage I or II CMHN between January 1, 2000 and December 31, 2015.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty percent (33\/168) of the patients developed a recurrence. Sixty\u2010six percent (4\/6) of patients who developed local recurrence first and 50% (3\/6) of patients who developed regional recurrence first were alive without evidence (NED) of disease at last follow\u2010up, while 0% (0\/21) of patients who developed distant or simultaneous recurrences first were NED at last follow\u2010up. Among the 7 patients who were NED, the mean time from recurrence to last follow\u2010up was 735\u2009days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Of patients with isolated local or regional recurrences, 58% (7\/12) obtained durable curative treatment for recurrent melanoma.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.25562","type":"journal-article","created":{"date-parts":[[2019,1,10]],"date-time":"2019-01-10T18:36:59Z","timestamp":1547145419000},"page":"1304-1311","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Patterns of recurrence and retreatment outcomes among clinical stage I and II head and neck melanoma patients"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1686-3698","authenticated-orcid":false,"given":"Arya W.","family":"Namin","sequence":"first","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery University of Missouri  Columbia Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgeanne E.","family":"Cornell","sequence":"additional","affiliation":[{"name":"Kansas City University of Medicine and Biosciences  Kansas City Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lori A.","family":"Thombs","sequence":"additional","affiliation":[{"name":"Department of Statistics University of Missouri  Columbia Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"III","given":"Robert P.","family":"Zitsch","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery University of Missouri  Columbia Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,1,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198412000-00017"},{"key":"e_1_2_8_3_1","unstructured":"National Comprehensive Cancer Network. 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