{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:07:30Z","timestamp":1747148850857,"version":"3.40.5"},"reference-count":8,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,12,27]],"date-time":"2018-12-27T00:00:00Z","timestamp":1545868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head & Neck"],"published-print":{"date-parts":[[2019,4]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Human papilloma virus (HPV)\u2010associated malignancies are considered to be sexually transmitted diseases.<\/jats:p><\/jats:sec>Methods<\/jats:title>We report a HPV\u2010positive larynx cancer in an 18\u2010year\u2010old female clarinet player, despite vaccination with the quadrivalent HPV\u20106\u201011\u201016\u201018\u2010vaccine Gardasil (Merck Sharp & Dohme Corp., West Point, Pennsylvania). The patient showed no evidence of genito\u2010oral infection but showed some evidence for oral\u2010oral HPV transmission through the sharing of saliva\u2010infested clarinet mouthpieces. A right vocal cord lesion of benign appearance was removed via free margin resection.<\/jats:p><\/jats:sec>Results<\/jats:title>Histopathology revealed a microinvasive squamous cell carcinoma inside a zone of high\u2010grade dysplasia that was positive for HPV\u201045. No tumor recurrence was observed during a 4\u2010year follow\u2010up evaluation.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Benign lesion appearance and quadrivalent HPV vaccine status do not exclude HPV\u2010associated malignancies. In our patient, the Gardasil vaccine did not provide crossover protection against HPV 45 infection. HPV\u2010associated disease may not necessarily be transmitted via sexual practice patterns alone.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.25572","type":"journal-article","created":{"date-parts":[[2018,12,27]],"date-time":"2018-12-27T10:41:00Z","timestamp":1545907260000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Human papilloma virus\u2010associated squamous cell carcinoma of the larynx in an 18\u2010year\u2010old woman"],"prefix":"10.1002","volume":"41","author":[{"given":"Michel\u2010Andr\u00e9","family":"Hotz","sequence":"first","affiliation":[{"name":"Department of ENT, Head and Neck Surgery, Inselspital University of Bern Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brigitte","family":"Christen","sequence":"additional","affiliation":[{"name":"Admed Pathologie Neuch\u00e2tel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Sahli","sequence":"additional","affiliation":[{"name":"Institute of Microbiology Centre Hospitalier Universitaire Vaudois and University of Lausanne Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9349-3312","authenticated-orcid":false,"given":"Andreas Michael","family":"Arnold","sequence":"additional","affiliation":[{"name":"Department of ENT, Head and Neck Surgery, Inselspital University of Bern Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,12,27]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-9785(83)80033-7"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmoldx.2011.03.007"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.05039-11"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2013.07.011"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23792"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29965"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djs395"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPYB6C4HIMLZIX"}],"container-title":["Head & Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.25572","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.25572","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hed.25572","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.25572","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T20:39:23Z","timestamp":1694119163000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.25572"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,27]]},"references-count":8,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["10.1002\/hed.25572"],"URL":"https:\/\/doi.org\/10.1002\/hed.25572","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"type":"print","value":"1043-3074"},{"type":"electronic","value":"1097-0347"}],"subject":[],"published":{"date-parts":[[2018,12,27]]},"assertion":[{"value":"2017-10-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}