{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,28]],"date-time":"2025-06-28T11:26:19Z","timestamp":1751109979517,"version":"3.40.5"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,1,11]],"date-time":"2019-01-11T00:00:00Z","timestamp":1547164800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81772879","81301791","81072406","30901326","81300510","31270971","31300752","31470885"],"award-info":[{"award-number":["81772879","81301791","81072406","30901326","81300510","31270971","31300752","31470885"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To evaluate the prognostic value of preoperative neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) in oral, pharyngeal, and lip cancer for survival and relapse.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Clinic\u2010pathologic and hematological records were retrospectively retrieved. Patients completed follow\u2010up period were included for survival and relapse analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The preoperative NLR value was a prognostic factor for both overall survival and relapse\u2010free survival. The high NLR group demonstrated higher total relapse rate, higher local relapse rate, and higher relapse rate within 12\u2009months. However, the preoperative PLR did not associate with survival or relapse.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The preoperative NLR, not PLR, is an independent prognostic indicator of survival. It also exhibits predictive value for relapse, particularly early relapse within 12\u2009months. The preoperative NLR value might be recommended as a useful tool for predicting the outcomes and stratifying patients for different management strategies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.25580","type":"journal-article","created":{"date-parts":[[2019,1,11]],"date-time":"2019-01-11T14:28:45Z","timestamp":1547216925000},"page":"1468-1474","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Preoperative neutrophil lymphocyte ratio but not platelet lymphocyte ratio predicts survival and early relapse in patients with oral, pharyngeal, and lip cancer"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2737-9674","authenticated-orcid":false,"given":"Wenjie","family":"Yu","sequence":"first","affiliation":[{"name":"Institute of Basic Medical Sciences, Qilu Hospital of Shandong University  Jinan Shandong China"},{"name":"Department of Oncology Yantai affiliated Hospital of Binzhou Medicial University  Yantai Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7698-6791","authenticated-orcid":false,"given":"Yu","family":"Dou","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery and Institution of Dental Medicine Qilu Hospital of Shandong University  Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ketao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery and Institution of Dental Medicine Qilu Hospital of Shandong University  Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanguo","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Basic Medical Sciences, Qilu Hospital of Shandong University  Jinan Shandong China"},{"name":"Department of Medical Oncology Qilu Hospital of Shandong University  Jinan Shandong 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