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In Stockholm, the proportion of human papillomavirus (HPV)\u2010positive cases and the incidence of TSCC rose between 1970 and 2006 then stabilized. Here, HPV\u2010prevalence, and TSCC\/BOTSCC incidence 2000\u20102016, in Stockholm and Sweden were followed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Incidence data for 2000\u20102016 were obtained from the Swedish Cancer Registry. TSCC\/BOTSCC biopsies, 2013\u20102016 from Stockholm, were examined for HPV DNA and p16<jats:sup>INK4a<\/jats:sup>, or data obtained from medical reports. For cases 2000\u20102012, data were available from previous studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The incidence of TSCC\/BOTSCC has continued to rise in Stockholm and Sweden 2000\u20102016, especially after 2008. HPV DNA and p16<jats:sup>INK4a<\/jats:sup> analysis was determined for 795 Stockholm cases from 2000 to 2016, with 72% being HPV DNA and p16<jats:sup>INK4a<\/jats:sup> positive 2013\u20102016, and 70% positive 2000\u20102016.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>During 2000\u20102016, especially after 2008, the incidence of TSCC\/BOTSCC has continued to increase in Stockholm and Sweden, with an HPV\u2010prevalence of approximately 70% in Stockholm.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.25585","type":"journal-article","created":{"date-parts":[[2018,12,25]],"date-time":"2018-12-25T01:24:27Z","timestamp":1545701067000},"page":"1583-1590","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":74,"title":["Changes in incidence and prevalence of human papillomavirus in tonsillar and base of tongue cancer during 2000\u20102016 in the Stockholm region and Sweden"],"prefix":"10.1002","volume":"41","author":[{"given":"Linnea","family":"Haeggblom","sequence":"first","affiliation":[{"name":"Department of Oncology\u2010Pathology Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tove","family":"Attoff","sequence":"additional","affiliation":[{"name":"Department of Oncology\u2010Pathology Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingru","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Holzhauser","sequence":"additional","affiliation":[{"name":"Department of Oncology\u2010Pathology Karolinska Institutet  Stockholm 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