{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:52:27Z","timestamp":1787507547846,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,1,12]],"date-time":"2019-01-12T00:00:00Z","timestamp":1547251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To define the prognostic factors associated with outcome in patients with soft palate squamous cell carcinoma (SCC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Previously untreated patients with soft palate and uvula SCC treated in our institution between 1997 and 2012 were collected. The prognostic value of clinical, hematological, and treatment characteristics was examined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We identified 156 patients, median age 58\u2009years, with 71% drinkers, 91% smokers; 19% had synchronous cancer. Front\u2010line treatment was chemoradiotherapy in 58 (37%), radiotherapy alone in 60 (39%), surgery in 17 (11%), and induction chemotherapy in 21 patients (14%). The 5\u2010year actuarial overall survival (OS) and progression\u2010free survival (PFS) were 41% and 37%, respectively. In univariate analysis, T3\u2010T4 vs T1\u2010T2 stage, N2\u2010N3 vs N0\u2010N1 stage, and neutrophil count &gt;7\u2009g\/L were associated with worse OS and PFS (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In patients with soft palate SCC, inflammation biomarkers were associated with OS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.25598","type":"journal-article","created":{"date-parts":[[2019,1,12]],"date-time":"2019-01-12T12:05:36Z","timestamp":1547294736000},"page":"1441-1449","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Prognostic factors in patients with soft palate squamous cell carcinoma"],"prefix":"10.1002","volume":"41","author":[{"given":"Antoine","family":"Schernberg","sequence":"first","affiliation":[{"name":"Radiation Oncology Department Gustave Roussy Cancer Campus  Paris France"},{"name":"INSERM1030, Gustave Roussy Cancer Campus  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Canova","sequence":"additional","affiliation":[{"name":"Radiation Oncology Department Gustave Roussy Cancer Campus  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Blanchard","sequence":"additional","affiliation":[{"name":"Radiation Oncology Department Gustave Roussy Cancer Campus  Paris France"},{"name":"Facult\u00e9 de M\u00e9decine du Kremlin\u2010Bicetre Universit\u00e9 Paris Sud, Universit\u00e9 Paris Saclay  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7604-4964","authenticated-orcid":false,"given":"Philippe","family":"Gorphe","sequence":"additional","affiliation":[{"name":"Head and Neck Oncology Department Gustave Roussy Cancer Campus  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Breuskin","sequence":"additional","affiliation":[{"name":"Head and Neck Oncology Department Gustave Roussy Cancer Campus  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haitham","family":"Mirghani","sequence":"additional","affiliation":[{"name":"Head and Neck Oncology Department Gustave Roussy Cancer Campus  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Moya\u2010Plana","sequence":"additional","affiliation":[{"name":"Head and Neck Oncology Department Gustave Roussy Cancer Campus  Paris 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MatsuokaY YoshidaR et al.Pre\u2010treatment neutrophil to lymphocyte ratio predicts the chemoradiotherapy outcome and survival in patients with oral squamous cell carcinoma: a retrospective study [Internet]. BMC Cancer. 2016; 16(1).http:\/\/www.biomedcentral.com\/1471-2407\/16\/41. 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