{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T04:10:07Z","timestamp":1784693407274,"version":"3.55.0"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,12,24]],"date-time":"2018-12-24T00:00:00Z","timestamp":1545609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>\n<jats:sup>18<\/jats:sup>F\u2010FDOPA PET\/CT was proved to be a highly sensitive imaging method for detecting head and neck paraganglioma (HNPGL). The primary aim of the study was to evaluate the relationship between tumor characteristics and the <jats:italic>SDHx\u2010<\/jats:italic>mutational status in a large series of patients with HNPGL evaluated by <jats:sup>18<\/jats:sup>F\u2010FDOPA PET\/CT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 104 patients with HNPGL (65 sporadic\/39 <jats:italic>SDHx<\/jats:italic>\u2010mutated) were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In comparison to <jats:italic>SDHB\/SDC\/SDHx<\/jats:italic>\u2010negative cases, patients with <jats:italic>SDHD<\/jats:italic> were younger at diagnosis and had a higher rate of multifocal, vagal, and carotid paraganglioma. In patients with <jats:italic>SDHD<\/jats:italic>, vagal paraganglia represented the primary site of tumor origin. Multicentric involvement of the vagus nerve alone or in association with other locations was found to be a typical feature of <jats:italic>SDHD<\/jats:italic> cases compared to other cases (odds ratio\u2009=\u200959.4).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The present study shows that tumor multifocality within the vagus nerve is a phenotypic marker of <jats:italic>SDHD<\/jats:italic> mutation. This information is essential in the choice of the therapeutic strategy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.25604","type":"journal-article","created":{"date-parts":[[2018,12,25]],"date-time":"2018-12-25T01:19:08Z","timestamp":1545700748000},"page":"1565-1571","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Tumor multifocality with vagus nerve involvement as a phenotypic marker of <i>SDHD<\/i> mutation in patients with head and neck paragangliomas: A <sup>18<\/sup>F\u2010FDOPA PET\/CT study"],"prefix":"10.1002","volume":"41","author":[{"given":"Vincent","family":"Amodru","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Conception University Hospital Aix\u2010Marseille University  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Romanet","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biology Conception Hospital &amp; 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