{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T03:20:33Z","timestamp":1785900033003,"version":"3.56.0"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,1,11]],"date-time":"2019-01-11T00:00:00Z","timestamp":1547164800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In this prospective nonrandomized multicenter trial, we analyze the incidence of early and late complications after parotidectomy in correlation to the extent of dissection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 148 patients underwent a parotidectomy for a benign lesion in the superficial lobe. The number of intraoperatively dissected main facial nerve branches was photo\u2010documented and defined the extent of tissue dissection. Early postoperative complications including sialocele were evaluated until 4\u2009weeks after surgery. Late complications as facial nerve palsy, Frey's syndrome (FS) and the outcome of the scar and substance loss were furthermore assessed after 6 and 12\u2009months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Early complications occurred in 22 patients (14%) and did not depend on the extent of facial nerve dissection (all <jats:italic>P<\/jats:italic> &gt;\u2009.05). However, patients with higher number of intraoperatively dissected facial nerve branches showed significantly higher palsy scores on the first postoperative day (<jats:italic>P<\/jats:italic> =\u2009.026). FS occurred with incidence of 69% and correlated significantly to the extent of dissection (<jats:italic>P<\/jats:italic> =\u2009.003). Appearance of the scar and substance loss improved significantly during the follow\u2010up (<jats:italic>P<\/jats:italic> &lt;\u2009.001 and <jats:italic>P<\/jats:italic> &lt;\u2009,005, respectively) without significant correlation to the extent of dissection (<jats:italic>P<\/jats:italic> &gt;\u2009.05 for both variables after 12\u2009months).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Less extensive tissue dissection resulted in better postoperative facial nerve function on the first postoperative day and in lower incidence of FS after 12\u2009months. However, incidence of early complications did not depend on the extent of surgery.<\/jats:p><jats:p>The study was registered in the German Clinical Trials Register prior to conducting the research. DRKS\u2010ID: DRKS00008967, URL:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/apps.who.int\/trialsearch\/\">http:\/\/apps.who.int\/trialsearch\/<\/jats:ext-link>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.25651","type":"journal-article","created":{"date-parts":[[2019,1,11]],"date-time":"2019-01-11T13:35:05Z","timestamp":1547213705000},"page":"1943-1951","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Impact of extent of parotidectomy on early and long\u2010term complications: A prospective multicenter cohort trial"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5985-468X","authenticated-orcid":false,"given":"Maria","family":"Grosheva","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carina","family":"Pick","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thordis","family":"Granitzka","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery Jena University Hospital  Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Sommer","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery University of Giessen  Giessen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus","family":"Wittekindt","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery University of Giessen  Giessen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens Peter","family":"Klussmann","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery University of Cologne  Cologne Germany"},{"name":"Department of Otolaryngology, Head and Neck Surgery University of Giessen  Giessen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9671-0784","authenticated-orcid":false,"given":"Orlando","family":"Guntinas\u2010Lichius","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery Jena University Hospital  Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Beutner","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery University of Cologne  Cologne Germany"},{"name":"Department of Otolaryngology, Head and Neck Surgery University of Goettingen  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