{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T07:23:02Z","timestamp":1787901782539,"version":"build-2784847793"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There are no proven systemic therapies for metastatic adenocarcinoma of the salivary glands. Pemetrexed use in adenocarcinoma of the salivary glands has not been previously described.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective case reports and literature review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two patients with metastatic salivary gland adenocarcinoma were treated with single\u2010agent pemetrexed with marked response and clinical benefit. Case 1 describes a sustained clinical response for 8\u2009months after failing several lines of chemotherapy. Case 2 describes a marked interval response of diffuse metastatic disease at 2\u2009months with resolution of bone pain and sustained response at 8\u2009months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>To our knowledge, this is the first report of efficacy of single\u2010agent pemetrexed for metastatic salivary gland adenocarcinoma. Given the significant and sustained responses in heavily pretreated patients, further investigation of pemetrexed for salivary cancer may be warranted.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.25658","type":"journal-article","created":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T12:59:53Z","timestamp":1549025993000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Marked responses to pemetrexed chemotherapy for metastatic adenocarcinoma of the parotid gland: Case series"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0834-8688","authenticated-orcid":false,"given":"Paul V.","family":"Viscuse","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Mayo Clinic  Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharine","family":"Price","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology Mayo Clinic  Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,2]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2009.10.004"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599815607449"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2017.0101"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41199-016-0011-z"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20327"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/COC.0000000000000112"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2013.468"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24745"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23940"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2015.0040"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx771"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1586\/14737140.2.1.13"},{"issue":"1","key":"e_1_2_4_14_1","doi-asserted-by":"crossref","first-page":"e9","DOI":"10.3747\/co.19.891","article-title":"Role of pemetrexed in advanced non\u2010small\u2010cell lung cancer: meta\u2010analysis of randomized controlled trials, with histology subgroup analysis","volume":"19","author":"Al\u2010Saleh K","year":"2012","journal-title":"Curr Oncol"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1801005"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/COC.0000000000000429"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.25658","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.25658","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hed.25658","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.25658","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T12:30:38Z","timestamp":1694349038000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.25658"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":15,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["10.1002\/hed.25658"],"URL":"https:\/\/doi.org\/10.1002\/hed.25658","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2]]},"assertion":[{"value":"2018-04-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}