{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T12:34:47Z","timestamp":1763037287935,"version":"3.40.5"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of our study was to document 10\u2010year outcome after curative \u201cexclusive\u201d chemotherapy in N0M0 squamous cell carcinoma of the larynx and pharynx.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective nonrandomized analysis of an inception cohort of 191 patients. Platinum salt and 5\u2010fluorouracil were used in all patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The 3\u2010, 5\u2010, 10\u2010year overall actuarial survival and local control estimates were 83.3%, 74.4%, and 55.4% and 62.1%, 62.1%, and 55.3%, respectively. Main causes of death were metachronous second primary cancer (<jats:italic>n<\/jats:italic>\u2009=\u200939) and intercurrent disease (<jats:italic>n<\/jats:italic>\u2009=\u200928). No clinical variables were associated with increased risk of local recurrence. Salvage treatment resulted in 94.7% ultimate local control and 88.4% organ preservation. \u201cExclusive\u201d chemotherapy was considered \u201cbeneficial\u201d in 62.3% and \u201cdetrimental\u201d in 7.8% of cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The high rate of local recurrence may be thought not to justify this treatment. Nevertheless, many patients avoided surgery and remained free of disease. Therefore, this approach deserves further study in the era of immune checkpoints inhibitors.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.25674","type":"journal-article","created":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T13:01:11Z","timestamp":1549026071000},"page":"2190-2196","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Ten\u2010year outcome of curative \u201cexclusive\u201d chemotherapy in N0M0 squamous cell carcinoma of the larynx and pharynx with complete clinical response"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9721-6761","authenticated-orcid":false,"given":"Ollivier","family":"Laccourreye","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology \u2010 Head and Neck Surgery Universit\u00e9 Paris Descartes Sorbonne Paris Cit\u00e9, H\u00f4pital Europ\u00e9en Georges Pompidou  Paris 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