{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T14:03:40Z","timestamp":1760709820595,"version":"3.40.5"},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,2,5]],"date-time":"2019-02-05T00:00:00Z","timestamp":1549324800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To evaluate clinical outcome and functional larynx preservation after radiotherapy (RT) for adenoid cystic carcinoma (ACC) of the larynx.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eleven patients with primary ACC of the larynx, who received RT definitely (<jats:italic>n<\/jats:italic>\u2009=\u20095\/11) or postoperatively (<jats:italic>n<\/jats:italic>\u2009=\u20096\/11), were analyzed regarding survival and treatment\u2010related toxicity with the focus on functional larynx preservation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median follow\u2010up was 45\u2009months. RT offered an excellent 5\u2010year local control (LC) rate of 100%. Eight of 11 patients were treated with a laryngeal preservation approach (LPA). At last follow\u2010up, only one of these eight patients developed a local recurrence requiring a total laryngectomy 11\u2009years after treatment. Severe toxicity was uncommon, with only one patient with LPA, requiring a temporary tracheostomy during therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>RT is an effective treatment method for laryngeal ACC with excellent LC rates, preservation of the laryngeal function and voice formation, representing a valuable therapy alternative to total laryngectomy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.25678","type":"journal-article","created":{"date-parts":[[2019,2,6]],"date-time":"2019-02-06T04:05:31Z","timestamp":1549425931000},"page":"2208-2214","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The role of organ\u2010 and function\u2010preserving radiotherapy in the treatment of adenoid cystic carcinoma of the larynx"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8363-2668","authenticated-orcid":false,"given":"Sati","family":"Akbaba","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology University Hospital Heidelberg  Heidelberg Germany"},{"name":"Department of Radiation Oncology, Heidelberg Institute of Radiation Oncology (HIRO)  Heidelberg Germany"},{"name":"Department of Radiation Oncology, Heidelberg Ion\u2010Beam Therapy Center (HIT)  Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5355-3173","authenticated-orcid":false,"given":"Kristin","family":"Lang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University Hospital Heidelberg  Heidelberg Germany"},{"name":"Department of Radiation Oncology, Heidelberg Institute of Radiation Oncology (HIRO)  Heidelberg Germany"},{"name":"Department of Radiation Oncology, Heidelberg Ion\u2010Beam Therapy Center (HIT)  Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olcay Cem","family":"Bulut","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery University Hospital Heidelberg  Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Held","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University Hospital Heidelberg  Heidelberg Germany"},{"name":"Department of Radiation Oncology, Heidelberg Institute of Radiation Oncology (HIRO)  Heidelberg Germany"},{"name":"Department of Radiation Oncology, Heidelberg Ion\u2010Beam Therapy Center (HIT)  Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Rieken","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University Hospital Heidelberg  Heidelberg Germany"},{"name":"Department of 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