{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T15:49:35Z","timestamp":1778600975776,"version":"3.51.4"},"reference-count":47,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,2,13]],"date-time":"2019-02-13T00:00:00Z","timestamp":1550016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81373071"],"award-info":[{"award-number":["81373071"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study was to investigate the association of fasting serum glucose (FSG), thyroid\u2010stimulating hormone (TSH), and thyroid hormones with papillary thyroid cancer (PTC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 649 participants were included in this case\u2010control study. The associations of FSG, TSH, free triiodothyronine (FT3) and free thyroxine (FT4) with PTC were estimated using an unconditional logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with the lowest quintile of TSH levels, odds ratios (ORs) and 95% confidence intervals (CIs) for association between PTC risk and highest quintile of TSH levels were 1.67 (95% CI, 0.99\u20102.83). However, this risk correlation was more significant in PTC cases with \u22641.0 cm tumor size (adjusted OR, 1.95; 95% CI, 1.08\u20103.54; adjusted <jats:italic>P<\/jats:italic>\u2010trend, 0.05). The PTC risk was also inversely associated with the serum FT3 level in all participants (adjusted <jats:italic>P<\/jats:italic>\u2010trend, 0.001), but positively associated with the serum FT4 (adjusted <jats:italic>P<\/jats:italic>\u2010trend, 0.001) and FSG (adjusted <jats:italic>P<\/jats:italic>\u2010trend, 0.01) levels. Among the participants without diabetes, the individuals with high FSG levels and abnormal TSH concentration had an increased PTC risk (adjusted OR, 3.38; 95% CI, 1.78\u20106.42).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The current study provides evidence for the association of FSG, TSH, and thyroid hormones (FT3 and FT4) with PTC risk. However, larger relative studies are needed.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.25691","type":"journal-article","created":{"date-parts":[[2019,2,13]],"date-time":"2019-02-13T19:25:03Z","timestamp":1550085903000},"page":"2277-2284","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Fasting serum glucose, thyroid\u2010stimulating hormone, and thyroid hormones and risk of papillary thyroid cancer: A case\u2010control study"],"prefix":"10.1002","volume":"41","author":[{"given":"Ming\u2010Jun","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health Anhui Medical University  Hefei Anhui China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health Anhui Medical University  Hefei Anhui China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health Anhui Medical University  Hefei Anhui China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng\u2010Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Head and Neck, Breast Surgery Anhui Provincial Cancer Hospital, West Branch of Anhui Provincial Hospital, First Affiliated Hospital of University of Science and Technology of China  Hefei Anhui China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu\u2010Cai","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Head and Neck, Breast Surgery Anhui Provincial Cancer Hospital, West Branch of Anhui Provincial Hospital, First Affiliated Hospital of University of Science and Technology of China  Hefei Anhui China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health Anhui Medical University  Hefei Anhui China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun\u2010Xiao","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health Anhui Medical University  Hefei Anhui China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health Anhui Medical University  Hefei Anhui China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2127-3668","authenticated-orcid":false,"given":"Fen","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health Anhui Medical University  Hefei Anhui China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,2,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21332"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.2719"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-016-0491-z"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-15-0445"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwv048"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2010-0003"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000002893"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.74.5497"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-018-0853-9"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-16-0845"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dju097"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-3901"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/5850879"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000000626"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-1640"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2013.0131"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-17-1903"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-14-985"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000201"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-006-0207-6"},{"issue":"18","key":"e_1_2_7_22_1","first-page":"2210","article-title":"Fasting serum glucose level and cancer risk in Korean men and women","volume":"293","author":"Nath SD","year":"2005","journal-title":"JAMA"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2013.01.009"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2009.124560"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2015.0020"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2016.12.011"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/530721"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2009.08.028"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1015557108"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-12-0219"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21387"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwu220"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2009.06.005"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f2360"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2015.0116"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-16-0328"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-1083"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.1046"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2010.11.011"},{"issue":"7","key":"e_1_2_7_40_1","first-page":"11379","article-title":"An epidemiological study of risk factors of thyroid nodule and goiter in Chinese women","volume":"8","author":"Zheng L","year":"2015","journal-title":"Int J Clin Exp Med"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2536"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-010-9134-4"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/1746-1596-8-180"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2008.11.010"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0350-5"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1210944"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.07.033"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09586"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.25691","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.25691","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hed.25691","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.25691","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T09:12:58Z","timestamp":1694337178000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.25691"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,13]]},"references-count":47,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["10.1002\/hed.25691"],"URL":"https:\/\/doi.org\/10.1002\/hed.25691","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,13]]},"assertion":[{"value":"2018-04-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}