{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T16:11:01Z","timestamp":1783181461013,"version":"3.54.6"},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,3,4]],"date-time":"2019-03-04T00:00:00Z","timestamp":1551657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Radiation\u2010induced bilateral external auditory canal cancer is an extremely rare disease that has yet to be fully characterized in the clinical literature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Herein, we present a case study of a 75\u2010year\u2010old man with radiation\u2010induced bilateral external auditory canal cancer. The patient's medical history included left maxillary cancer that had been treated with chemoradiation 19\u2009years earlier and local recurrence with total maxillectomy 10\u2009years earlier. Intracavitary radiation was delivered to the site of postoperative recurrence 8\u2009years before the current presentation. The patient declined radical surgery for the external auditory canal cancer at this time, and a customized combined modality regimen was thus administered.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was no recurrence of cancer for 22 months, to date, after completing chemoradiotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our finding that radiotherapy can be successfully used for radiation\u2010induced cancer indicates that chemoradiotherapy may be a useful strategy for treating this type of malignancy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.25728","type":"journal-article","created":{"date-parts":[[2019,3,4]],"date-time":"2019-03-04T09:38:00Z","timestamp":1551692280000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effectiveness of chemoradiotherapy for radiation\u2010induced bilateral external auditory canal cancer: A case report and literature review"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6302-1982","authenticated-orcid":false,"given":"Toshiya","family":"Maebayashi","sequence":"first","affiliation":[{"name":"Department of Radiology Nihon University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoya","family":"Ishibashi","sequence":"additional","affiliation":[{"name":"Department of Radiology Nihon University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Aizawa","sequence":"additional","affiliation":[{"name":"Department of Radiology Nihon University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masakuni","family":"Sakaguchi","sequence":"additional","affiliation":[{"name":"Department of Radiology Nihon University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsuo","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Nihon University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryoji","family":"Hirai","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Nihon University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tohru","family":"Furusaka","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Nihon University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taku","family":"Homma","sequence":"additional","affiliation":[{"name":"Department of Human Pathology, Division of Pathology and Microbiology Nihion University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e3181e711a0"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e3181839b8c"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3342\/kjorl-hns.2016.16698"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.12923"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2004.06.712"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1976.00780070090014"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100115087"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3950\/jibiinkoka.104.514"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200206000-00012"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-007-0274-4"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00106-005-1220-7"},{"key":"e_1_2_9_13_1","first-page":"106","article-title":"Bilateral squamous carcinoma of the external auditory canal\u2014a case report","volume":"39","author":"Dorobisz K","year":"2015","journal-title":"Pol Merkur Lekarski"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2005.11.012"},{"key":"e_1_2_9_15_1","first-page":"811","article-title":"Second cancers following radiotherapy of malignant tumors. 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