{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T23:52:38Z","timestamp":1783122758017,"version":"3.54.6"},"reference-count":40,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,4,7]],"date-time":"2019-04-07T00:00:00Z","timestamp":1554595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The efficacy of parathyroidectomy for primary and secondary hyperparathyroidism is well\u2010established but evidence in tertiary hyperparathyroidism is lacking. We examined parathyroidectomy's effect in tertiary hyperparathyroidism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with tertiary hyperparathyroidism who underwent parathyroidectomy were followed up for 12\u2009months. A modification of the 13\u2010item parathyroid symptoms list developed by Pasieka was administered at 0, 1, 3, 6, and 12\u2009months post\u2010surgery. We also examined if preoperative factors would predict symptom improvement post\u2010surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ninety\u2010one patients were included. Survey response rates at 1, 3, 6, and 12\u2009months post\u2010surgery were 97.8%, 90.1%, 82.4%, and 80.2%, respectively. Mean preoperative Pasieka parathyroid score (PSS) was 6.3 \u00b1 2.7. At first month, PSS decreased to 2.9 \u00b1 2.0 (<jats:italic>P<\/jats:italic> &lt;\u2009.001) and was sustained at 3, 6, and 12\u2009months (2.7 \u00b1 2.1, <jats:italic>P<\/jats:italic> &lt;\u2009.001, 2.3 \u00b1 1.6, <jats:italic>P<\/jats:italic> &lt;\u2009.001 and 3.4 \u00b1 2.5, <jats:italic>P<\/jats:italic> &lt;\u2009.001). The degree of PSS reduction at 1\u2010month post\u2010parathyroidectomy correlated strongly with preoperative symptom severity (Pearson's coefficient: 0.690, <jats:italic>P<\/jats:italic> &lt;\u2009.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Parathyroid symptoms unequivocally improve post\u2010parathyroidectomy. The greatest degree of improvement was observed in early postoperative period up to 6 months.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.25750","type":"journal-article","created":{"date-parts":[[2019,4,8]],"date-time":"2019-04-08T06:06:01Z","timestamp":1554703561000},"page":"2748-2755","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The effect of parathyroidectomy on patients' symptoms in tertiary hyperparathyroidism"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2126-4665","authenticated-orcid":false,"given":"Anna","family":"See","sequence":"first","affiliation":[{"name":"Singhealth Duke\u2010NUS Head &amp; Neck Centre  Singapore Singapore"},{"name":"Department of Otolaryngology Sengkang General Hospital  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy E. 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