{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T05:46:16Z","timestamp":1771307176546,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 CA008748"],"award-info":[{"award-number":["P30 CA008748"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Standard treatment of squamous cell carcinoma (SCC) of the anterior nasal mucosa is surgical resection with or without postoperative radiation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective review of patients diagnosed with SCC of the nasal cavity between January 2000 and July 2018 who refused total rhinectomy and who were treated with radiation with or without chemotherapy with curative intent.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eleven patients were identified, 73% had stage III or stage IV disease. Four patients were treated with intensity\u2010modulated radiotherapy and seven with intensity\u2010modulated proton radiotherapy. Concurrent chemoradiotherapy was used in nine patients (82%). With a median follow\u2010up of 15\u2009months (3\u2010124\u2009months), two patients experienced recurrence and one developed distant metastasis and died from disease. The 2\u2010year rhinectomy\u2010free survival rate was 88%. Two\u2010year overall survival and recurrence\u2010free survival were 100% and 75%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A radiation\u2010based approach for SCC of the nasal cavity mucosa is a valid option for selected patients who refuse up\u2010front surgery.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.25751","type":"journal-article","created":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T13:08:41Z","timestamp":1554124121000},"page":"2741-2747","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Organ preservation for patients with anterior mucosal squamous cell carcinoma of the nasal cavity: Rhinectomy\u2010free survival in those refusing surgery"],"prefix":"10.1002","volume":"41","author":[{"given":"Ximena","family":"Mimica","sequence":"first","affiliation":[{"name":"Head and Neck Service, Department of Surgery Memorial Sloan Kettering Cancer Center  New York 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