{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:50:02Z","timestamp":1790175002464,"version":"4.1.0"},"reference-count":55,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,4,3]],"date-time":"2019-04-03T00:00:00Z","timestamp":1554249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"HPV-AHEAD","award":["FP7-HEALTH-2011-282562"],"award-info":[{"award-number":["FP7-HEALTH-2011-282562"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We investigated the role of the soft tissue tract between the primary tumor and the neck lymph nodes, the \u201cT\u2010N tract,\u201d in patients with tongue squamous cell carcinoma at an advanced stage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a compartmental tongue surgery in 233 patients. Cumulative incidence of relapses and overall survival curves were compared by T\u2010N tract involvement. Multivariate Cox proportional hazards models were used to assess the independent role of T\u2010N tract.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At 4\u2009years of follow\u2010up, patients with disease in the T\u2010N tract experienced a significantly more distant recurrence (40%) than did patients without T\u2010N tract involvement (22%; <jats:italic>P<\/jats:italic> =\u2009.02). Multivariate Cox models indicate a significant almost triple risk of distant metastases (hazard ratio [HR], 2.70; 95% CI, 1.01\u20107.19; <jats:italic>P<\/jats:italic> =\u2009.05) and double risk of death (HR, 2.09; 95%CI, 1.13\u20103.85; <jats:italic>P<\/jats:italic> =\u2009.02) in patients with \u201cT\u2010N tract involvement.\u201d<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our data show that the T\u2010N tract plays an important role in prognosis and survival in patients with tongue cancer.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.25761","type":"journal-article","created":{"date-parts":[[2019,4,3]],"date-time":"2019-04-03T15:27:31Z","timestamp":1554305251000},"page":"2756-2767","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["The role of the T\u2010N tract in advanced stage tongue 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