{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:37:27Z","timestamp":1791405447241,"version":"4.3.3"},"reference-count":36,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,4,15]],"date-time":"2019-04-15T00:00:00Z","timestamp":1555286400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Small cohort studies have suggested oral tongue squamous cell carcinoma (OTSCC) could be associated with worse prognosis in individuals younger than 40.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We compared the survival of all OTSCC cases in the National Cancer Database under 40\u2009years old with those older than 40, excluding patients over 70. Cox regression and propensity score matched (PSM) survival analyses were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 22\u2009930 OTSCC patients were identified. The under 40 group consisted of 2566 (9.9%) cases; 20664 were 40 to 70 (90.1%). Most were male (13\u2009713, 59.8%), stage I\u2010II (12\u2009754, 72.4%), and treated by surgery alone (13\u2009973, 63.2%). Survival in patients under 40 was higher (79.6% vs 69.5%, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). In PSM analysis (n\u2009=\u20092928) controlling for all 10 significant factors in multivariate regression, patients under 40 had a 9% higher 5\u2010year survival (77.1% vs 68.2%, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Contrary to the prior reports, younger patients with OTSCC did not have worse survival in the National Cancer Database.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.25772","type":"journal-article","created":{"date-parts":[[2019,4,15]],"date-time":"2019-04-15T11:54:10Z","timestamp":1555329250000},"page":"2960-2968","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Survival of oral tongue squamous cell carcinoma in young adults"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2664-7756","authenticated-orcid":false,"given":"Jamie R.","family":"Oliver","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, NYU School of Medicine  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Peter","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology NYU Langone Health  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clifford M.","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, NYU School of Medicine  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dylan F.","family":"Roden","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Thomas Jefferson University  Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binhuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Population Health NYU Langone Health  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth S.","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology NYU Langone Health  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Schreiber","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology SUNY Downstate Medical Center  Brooklyn New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8221-5077","authenticated-orcid":false,"given":"Babak","family":"Givi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology NYU Langone Health  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,4,15]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"American Cancer Society. American Cancer Society cancer facts & figures 2017 (2017).https:\/\/www.cancer.org\/content\/dam\/cancer\u2010org\/research\/cancer\u2010facts\u2010and\u2010statistics\/annual\u2010cancer\u2010facts\u2010and\u2010figures\/2017\/cancer\u2010facts\u2010and\u2010figures\u20102017.pdf. Accessed October 21 2018."},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.10004"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.10577"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24589"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.31.7883"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2017.02.019"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2880160202"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24898"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2006.10.013"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2013.07.005"},{"issue":"2","key":"e_1_2_6_12_1","first-page":"459","article-title":"Negative prognostic factors for head and neck cancer in the young","volume":"18","author":"Kourelis K","year":"2013","journal-title":"J BUON"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.3342\/ceo.2010.3.3.161"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.1030"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.14639\/0392-100X-1932"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23183"},{"key":"e_1_2_6_17_1","unstructured":"American College of Surgeons. National Cancer Database [online].https:\/\/www.facs.org\/quality-programs\/cancer\/ncdb. Accessed February 8 2018."},{"key":"e_1_2_6_18_1","volume-title":"International Histological Classification of Tumours","year":"2013"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2016.12.017"},{"key":"e_1_2_6_20_1","unstructured":"National Comprehensive Cancer Network. Head and Neck Cancers (Version 2.2018).http:\/\/www.nccn.org\/. Accessed February 24 2018."},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.moo.0000170529.04759.4c"},{"key":"e_1_2_6_22_1","unstructured":"Ho D.E. Stuart E. Imai K. King G.Package \u2018MatchIt\u2019.http:\/\/cran.rproject.org\/web\/packages\/MatchIt\/MatchIt.pdf. Accessed October 26 2010."},{"key":"e_1_2_6_23_1","volume-title":"R: A Language and Environment for Statistical Computing","author":"R Core Team","year":"2013"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.18538"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2015.03.010"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1967.75"},{"issue":"3","key":"e_1_2_6_27_1","first-page":"171","article-title":"Oral cancer among patients under the age of 35 years","volume":"47","author":"Iype EM","year":"2001","journal-title":"J Postgrad Med"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(200005)22:3<297::AID-HED14>3.0.CO;2-3"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1445-2197.2003.02818.x"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(00)70249-X"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(199808)20:5<363::AID-HED1>3.0.CO;2-W"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1017\/S002221511100332X"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2009.01.011"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.67.3863"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21600"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2015.3595"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599815622409"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.25772","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hed.25772","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.25772","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T02:49:53Z","timestamp":1692672593000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.25772"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,15]]},"references-count":36,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["10.1002\/hed.25772"],"URL":"https:\/\/doi.org\/10.1002\/hed.25772","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,15]]},"assertion":[{"value":"2018-12-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}