{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T23:36:59Z","timestamp":1778542619627,"version":"3.51.4"},"reference-count":21,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,4,26]],"date-time":"2019-04-26T00:00:00Z","timestamp":1556236800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head & Neck"],"published-print":{"date-parts":[[2019,9]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n To evaluate recategorization of pT1\u20103N0 oral tongue cancer, from seventh to eighth editions of the American Joint Committee on Cancer (AJCC) staging classification, and impact on overall survival (OS).<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Using the National Cancer Database, 1277 patients were categorized using tumor size and depth of invasion with seventh and eighth AJCC staging systems and evaluated for OS.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Tumor\u2010category was unchanged in 82.9% and upstaged in 17.1% patients with eighth AJCC. The 3\u2010year OS was 85.3%, 76.6%, and 77.0% with seventh AJCC compared to 87.1%, 75.1%, and 81% with eighth AJCC, for patients with pT1N0, pT2N0, and pT3N0 disease, respectively. Improved discrimination of pT1N0 vs pT2N0 for OS on multivariate analysis was seen for eighth AJCC (hazard ratio [HR]\u2009=\u20091.43, 95% confidence interval [CI]: 1.03\u20101.98,\n P<\/jats:italic>\n \u2009=\u2009.03) but not for patients with pT3N0, with seventh AJCC (HR\u2009=\u20091.02, 95% CI:0.53\u20101.98,\n P<\/jats:italic>\n \u2009=\u2009.95), and eighth AJCC (HR\u2009=\u20090.86, 95% CI: 0.52\u20101.42,\n P<\/jats:italic>\n \u2009=\u2009.55).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Eighth edition AJCC staging leads to improved discrimination of OS between pT1N0 and pT2N0 but not for patients with pT3N0.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/hed.25785","type":"journal-article","created":{"date-parts":[[2019,4,26]],"date-time":"2019-04-26T05:39:30Z","timestamp":1556257170000},"page":"2976-2982","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Recategorization of tumor stage in patients with node\u2010negative oral tongue cancer: Impact of the eighth edition American Joint Committee staging system"],"prefix":"10.1002","volume":"41","author":[{"given":"Rushil R.","family":"Dang","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Boston Medical Center Henry M. Goldman School of Dental Medicine Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad M.","family":"Qureshi","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Boston Medical center Boston University School of Medicine Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven J.","family":"Caldroney","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Boston Medical Center Henry M. Goldman School of Dental Medicine Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew R.","family":"Salama","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Boston Medical Center Henry M. Goldman School of Dental Medicine Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6662-4981","authenticated-orcid":false,"given":"Minh Tam","family":"Truong","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Boston Medical center Boston University School of Medicine Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,4,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-88441-7"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2014.1548"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1748-717X-5-43"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2011.03.060"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000343796"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-40618-3"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1506007"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20275"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21389"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2017.09.007"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2017.05.020"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2017.11.009"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2014.09.012"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2008.06.002"},{"key":"e_1_2_6_16_1","unstructured":"National Cancer Database.American College of Surgeons www.facs.org\/quality-programs\/cancer\/ncdb. 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