{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T18:43:00Z","timestamp":1760985780490,"version":"3.40.5"},"reference-count":34,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,4,29]],"date-time":"2019-04-29T00:00:00Z","timestamp":1556496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Anemia's effect on head and neck surgical complications is unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Head and neck cancer operations were acquired from the 2006 to 2013 American College of Surgeons National Surgical Quality Improvement Program databases. Anemia was defined as &lt;39% or &lt;36% hematocrit in men and women, respectively. Multivariable logistic regression analyses were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Major head and neck surgery patients had a 44.2% anemia incidence (n = 527 of 1193). Anemic patients had increased complication rates (27.1%) and mortality (2.1%) vs non\u2010anemic patients at 19.8% (<jats:italic>P<\/jats:italic> = .003) and 0.5% (<jats:italic>P<\/jats:italic> = .009), respectively. There was a significant difference in morbidity odds with hematocrit &gt;27% (odds ratio [OR] = 1.09) vs &lt;27% (OR = 4.22). Complication odds were further increased with hematocrit between 24% and 27% (OR = 8.94). There were increased rates of wound dehiscence (6.6% vs 2.7%, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001), pneumonia (8.5% vs 4.7%, <jats:italic>P<\/jats:italic> = .006), and myocardial infarction (1.7% vs 0.3%, <jats:italic>P<\/jats:italic> = .01) in anemic vs non\u2010anemic patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Anemia was associated with increased morbidity at hematocrit &lt;27%. An inverse dose\u2010dependent effect of decreasing hematocrit was observed for overall morbidity.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.25788","type":"journal-article","created":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:05:17Z","timestamp":1556669117000},"page":"3033-3040","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Preoperative anemia displays a dose\u2010dependent effect on complications in head and neck oncologic surgery"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2083-3523","authenticated-orcid":false,"given":"Nicholas B.","family":"Abt","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Massachusetts Eye and Ear Infirmary Harvard Medical School  Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Constantine","family":"Tarabanis","sequence":"additional","affiliation":[{"name":"Department of 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