{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T16:17:06Z","timestamp":1761581826267,"version":"3.40.5"},"reference-count":17,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,5,2]],"date-time":"2019-05-02T00:00:00Z","timestamp":1556755200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Fluorine\u201018\u2010labeled 1\u2010amino\u20103\u2010fluorocyclobutane\u20101\u2010carboxylic acid (fluciclovine) is a synthetic amino acid radiopharmaceutical initially developed to improve noninvasive diagnosis of gliomas and currently FDA approved for prostate cancer imaging. Although fluciclovine positron emission tomography (PET) has proven to be efficacious in detecting multiple types of cancer, its ability to detect oropharyngeal squamous cell carcinoma (OPSCC) is largely unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We describe a case of incidental OPSCC detection with fluciclovine PET in a 66\u2010year old male patient during workup for recurrent prostate adenocarcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fluciclovine PET detected a left base of tongue (BOT) lesion, which was subsequently confirmed as invasive SCC on surgical pathology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Given these findings, we discuss potential future directions for research with fluciclovine to overcome some of the known limitations of <jats:sup>18<\/jats:sup>[F]fluorodeoxyglucose in oncological imaging.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.25798","type":"journal-article","created":{"date-parts":[[2019,5,2]],"date-time":"2019-05-02T14:13:50Z","timestamp":1556806430000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Incidental detection of oropharyngeal cancer with fluciclovine PET"],"prefix":"10.1002","volume":"41","author":[{"given":"Amit","family":"Jethanandani","sequence":"first","affiliation":[{"name":"College of Medicine The University of Tennessee Health Science Center  Memphis Tennessee"},{"name":"Department of Radiation Oncology, Division of Radiation Oncology The University of Texas MD Anderson Cancer Center  Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa M.","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology, Division of Diagnostic Imaging The University of Texas MD Anderson Cancer Center  Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria K.","family":"Gule\u2010Monroe","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology, Division of Diagnostic Imaging The University of Texas MD Anderson Cancer Center  Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William H.","family":"Morrison","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Division of Radiation Oncology The University of Texas MD Anderson Cancer Center  Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen Y.","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Division of Radiation Oncology The University of Texas MD Anderson Cancer Center  Houston Texas"},{"name":"Department of Head and Neck Surgery, Division of Surgery The University of Texas MD Anderson Cancer Center  Houston Texas"},{"name":"Department of Molecular and Cellular Oncology The University of Texas MD Anderson Cancer Center  Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7724-5784","authenticated-orcid":false,"given":"Jason M.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology, Division of Diagnostic Imaging The University of Texas MD Anderson Cancer Center  Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,5,2]]},"reference":[{"issue":"2","key":"e_1_2_4_2_1","first-page":"331","article-title":"Synthesis and evaluation of [18F]1\u2010amino\u20103\u2010fluorocyclobutane 1\u2010carboxylic acid to image brain tumors","volume":"40","author":"Shoup TM","year":"1999","journal-title":"J Nucl 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2.2018.https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/head-and-neck.pdf. 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