{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T09:20:24Z","timestamp":1775121624965,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,6,4]],"date-time":"2019-06-04T00:00:00Z","timestamp":1559606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The aim of this study is to investigate and summarize the treatment efficacy and adverse effects (AEs) of sorafenib in the treatment of metastatic medullary thyroid carcinomas (MTCs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included studies reporting the treatment efficacy or drug toxicity of sorafenib as a single therapeutic agent in MTCs. Pooled incidence and its 95% confidence interval (CI) for complete response, partial response (PR), stable disease (SD), and sorafenib\u2010related AEs were calculated using random\u2010effect model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eight trials with 101 metastatic MTCs were included for meta\u2010analyses. The overall PR and SD were 21% (95% CI = 9\u201033) and 58% (95% CI = 41\u201075), respectively. Hand\u2010foot syndrome, diarrhea, alopecia, mucositis, skin rash, fatigue, and hypertension were the most commonly observed AEs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results show that sorafenib treatment has a modest effect and might be a candidate treatment in patients with metastatic MTCs who have failed other therapeutic regimens.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.25832","type":"journal-article","created":{"date-parts":[[2019,6,4]],"date-time":"2019-06-04T17:03:41Z","timestamp":1559667821000},"page":"2823-2829","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Efficacy and toxicity of sorafenib in the treatment of advanced medullary thyroid carcinoma: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6213-765X","authenticated-orcid":false,"given":"Huy Gia","family":"Vuong","sequence":"first","affiliation":[{"name":"Department of Pathology University of Yamanashi  Chuo Yamanashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"An Thi Nhat","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Medicine Medstar Harbor Hospital  Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thao T. K.","family":"Tran","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Medicine and Pharmacy  Ho Chi Minh City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaume","family":"Capdevila","sequence":"additional","affiliation":[{"name":"Medical Oncology Department Vall d'Hebron University Hospital, Universitat Autonoma de Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa","family":"Benekli","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Gazi University Faculty of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadao","family":"Nakazawa","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Yamanashi  Chuo Yamanashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryohei","family":"Katoh","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Yamanashi  Chuo Yamanashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuo","family":"Kondo","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Yamanashi  Chuo Yamanashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,6,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2014.0335"},{"key":"e_1_2_6_3_1","volume-title":"World Health Organization Classification of Tumours. 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