{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:08:05Z","timestamp":1747148885780,"version":"3.40.5"},"reference-count":20,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,6,19]],"date-time":"2019-06-19T00:00:00Z","timestamp":1560902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There is a lack of consensus regarding the management of T4a larynx cancer. We evaluated the outcomes of organ preservation and laryngectomy for T4a laryngeal cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective analysis of patients with T4a larynx cancer at BC Cancer from 1984 to 2014 was performed. Outcomes in patients treated with surgery alone (Sx) (n = 47), surgery with adjuvant radiotherapy (Sx\/RT) (n = 94), radiation alone (RT) (n = 152), and radiation with concurrent chemoradiotherapy (chemoRT) (n = 36) were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The 5\u2010year overall survival (OS) was 40% for chemoRT, 34% for RT, 23% for Sx, and 45% for Sx\/RT. On multivariate analysis (MVA), Sx\/RT (hazard ratio [HR], 0.66; 95% confidence interval [CI], 0.48\u20100.91) and chemoRT (HR, 0.44; 95% CI, 0.26\u20100.72) were associated with better OS than RT alone (<jats:italic>P<\/jats:italic> = .001). Sx had similar OS compared to RT (HR, 1.17; 95% CI, 0.82\u20101.68).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>ChemoRT and Sx\/RT were associated with better OS compared to single modality treatment. ChemoRT may be considered as an option for T4a larynx cancer.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.25838","type":"journal-article","created":{"date-parts":[[2019,6,19]],"date-time":"2019-06-19T10:11:02Z","timestamp":1560939062000},"page":"3265-3275","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Primary organ preservation vs total laryngectomy for T4a larynx cancer"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0921-8984","authenticated-orcid":false,"given":"Justin","family":"Oh","sequence":"first","affiliation":[{"name":"Department of Surgery, Faculty of Medicine University of British Columbia  Vancouver British Columbia Canada"},{"name":"Department of Radiation Oncology British Columbia Cancer \u2013 Vancouver Centre  Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7201-6181","authenticated-orcid":false,"given":"Eitan","family":"Prisman","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Medicine University of British Columbia  Vancouver British Columbia Canada"},{"name":"Department of Otolaryngology, Faculty of Medicine University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Olson","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Medicine University of British Columbia  Vancouver British Columbia Canada"},{"name":"Department of Radiation Oncology British Columbia Cancer \u2013 Centre for the North  Prince George British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Berthelet","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Medicine University of British Columbia  Vancouver British Columbia Canada"},{"name":"Department of Radiation Oncology British Columbia Cancer \u2013 Vancouver Centre  Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonn","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Medicine University of British Columbia  Vancouver British Columbia Canada"},{"name":"Department of Radiation Oncology British Columbia Cancer \u2013 Vancouver Centre  Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Tran","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Medicine University of British Columbia  Vancouver British Columbia Canada"},{"name":"Department of Radiation Oncology British Columbia Cancer \u2013 Vancouver Centre  Vancouver British Columbia 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