{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:08:28Z","timestamp":1772118508491,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,7,11]],"date-time":"2019-07-11T00:00:00Z","timestamp":1562803200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Timely postoperative radiation therapy (RT) within 50\u2009days of surgery for head and neck cancers provides a survival advantage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using the National Cancer Database, we performed a propensity score\u2010matched analysis comparing patients undergoing open or endoscopic surgery for squamous cell carcinoma (SCC) of the nasal cavity and paranasal sinuses from 2010 to 2015.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 168 pairs, patients undergoing endoscopic surgery had shorter time to surgery (24.2 vs 36.7 days,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001) and shorter postoperative time to RT (PTTR, 51.2 vs 58.4 days,\n                      <jats:italic>P<\/jats:italic>\n                      = .02). On multivariable linear regression, endoscopic surgery predicted shorter PTTR (\u03b2 = \u22127.6,\n                      <jats:italic>P<\/jats:italic>\n                      = .01). Using the Kaplan\u2010Meier method, patients in the longest PTTR quartile had decreased overall survival (OS; Q1 vs Q4, 3\u2010year OS 76.5% vs 53.3%,\n                      <jats:italic>P<\/jats:italic>\n                      = .007), a durable finding when adjusted for covariates (Q1 vs Q4, HR 0.50,\n                      <jats:italic>P<\/jats:italic>\n                      = .008).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients undergoing endoscopic surgery for sinonasal SCC experience shorter PTTR. Shorter PTTR is associated with extended OS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.25873","type":"journal-article","created":{"date-parts":[[2019,7,11]],"date-time":"2019-07-11T10:48:28Z","timestamp":1562842108000},"page":"3551-3563","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Timing of surgery and adjuvant radiation therapy for sinonasal malignancies: Effect of surgical approach"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4459-0746","authenticated-orcid":false,"given":"Roy","family":"Xiao","sequence":"first","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery Massachusetts Eye and Ear Infirmary, Harvard University  Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5833-4172","authenticated-orcid":false,"given":"Rohan 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