{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T02:16:05Z","timestamp":1767665765182,"version":"3.40.5"},"reference-count":27,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,7,16]],"date-time":"2019-07-16T00:00:00Z","timestamp":1563235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003500","name":"Universit\u00e0 degli Studi di Padova","doi-asserted-by":"publisher","award":["DOR1778819\/17"],"award-info":[{"award-number":["DOR1778819\/17"]}],"id":[{"id":"10.13039\/501100003500","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Neurofibromatosis type 2 (NF2) is an autosomal dominant, multiple neoplasia syndrome characterized by bilateral vestibular schwannomas (VSs). Endoglin is a proliferation\u2010associated protein expressed in angiogenic endothelial cells. The aim of this study was to investigate endoglin expression in a series of NF2\u2010associated VSs, as compared with a group of sporadic VSs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using image analysis, vessel cross\u2010sectional area (AA) and density (VD) were calculated from CD105 expression in 7 NF2\u2010associated VSs and 14 size\u2010matched sporadic VSs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were no significant differences between NF2\u2010associated VSs and sporadic cases in terms of AA (<jats:italic>P<\/jats:italic> = .28), or VD (<jats:italic>P<\/jats:italic> = .39). A positive correlation emerged between tumor growth rate (measured on contrast\u2010enhanced MRI) and VD in the cohort of NF2\u2010associated VSs (rho = 0.95, <jats:italic>P<\/jats:italic> = .05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Further investigations are needed to ascertain the feasibility of (a) measuring circulating endoglin levels to monitor tumor growth rate and (b) targeting tumor neoangiogenesis with anti\u2010endoglin approaches in NF2\u2010associated VS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.25881","type":"journal-article","created":{"date-parts":[[2019,7,17]],"date-time":"2019-07-17T06:54:09Z","timestamp":1563346449000},"page":"3612-3617","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Endoglin (CD105) expression in neurofibromatosis type 2 vestibular schwannoma"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8751-0588","authenticated-orcid":false,"given":"Gino","family":"Marioni","sequence":"first","affiliation":[{"name":"Department of Neuroscience, Otolaryngology Section Padova University  Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo","family":"Nicol\u00e8","sequence":"additional","affiliation":[{"name":"Department of Medicine Padova University  Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego","family":"Cazzador","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Otolaryngology Section Padova University  Padova Italy"},{"name":"Department of Neuroscience, Section of Human Anatomy Padova University  Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Pavone","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Otolaryngology Section Padova University  Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Domenico","family":"D'Avella","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Academic Neurosurgery, Padova University  Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Martini","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Otolaryngology Section Padova University  Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Mazzoni","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Otolaryngology Section Padova University  Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabetta","family":"Zanoletti","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Otolaryngology Section Padova University  Padova 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