{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T17:58:43Z","timestamp":1759341523998,"version":"3.40.5"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,7,24]],"date-time":"2019-07-24T00:00:00Z","timestamp":1563926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Early oral cavity cancer has good prognosis but recurrence in them is still not uncommon. There is no general consensus on the prognostic factors and adjuvant therapy that would have a significant impact on survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective analysis of early oral cavity cancer patients during the time period 2009\u20102017. The data regarding demographics, histopathological features, and recurrence patterns were collected and analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Depth of invasion (DOI) was the most important prognostic factor among all the factors analyzed. Further analysis showed that addition of adjuvant radiotherapy for patients with DOI &gt;5 mm did not show survival benefits (<jats:italic>P<\/jats:italic> = .73). Another subset analysis of patients with DOI &gt;10 mm also did not show any survival advantage with adjuvant therapy <jats:italic>P<\/jats:italic> = .24.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There is no benefit of adding adjuvant RT in patients with DOI\u2009&gt;\u20095 mm or in patients who were upstaged to T3 based only on DOI.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.25882","type":"journal-article","created":{"date-parts":[[2019,7,24]],"date-time":"2019-07-24T15:18:55Z","timestamp":1563981535000},"page":"3577-3583","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Early oral cavity cancer: The prognostic factors and impact of adjuvant radiation on survival"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5793-2931","authenticated-orcid":false,"given":"Suhas K.","family":"Rajappa","sequence":"first","affiliation":[{"name":"Department of Surgical Oncology Rajiv Gandhi Cancer Institute &amp; Research Centre  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3441-2241","authenticated-orcid":false,"given":"Udip","family":"Maheshwari","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Rajiv Gandhi Cancer Institute &amp; Research Centre  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0224-5012","authenticated-orcid":false,"given":"Dharma","family":"Ram","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology Rajiv Gandhi Cancer Institute &amp; Research Centre  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Venkata P. 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