{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T03:45:30Z","timestamp":1789271130475,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T00:00:00Z","timestamp":1565136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To evaluate the differences in treatment modality and outcomes between male and female patients with laryngeal squamous cell carcinoma (SCC) in the United States.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were extracted from the Surveillance, Epidemiology, and End Results Database for patients with laryngeal SCC (2004\u20102013). Overall survival (OS), disease specific survival (DSS), and multivariate analyses were conducted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among women, supraglottic cancers were the most prevalent (61.2%); whereas the majority of men developed glottic cancers (64.2%; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). Women with T4 disease were more likely to undergo primary radiation (56.8% vs 45.3%; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001) and less likely to undergo open surgery were than men (37.1% vs 48.2%; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). Women had significantly better OS in glottic and supraglottic cancers, and comparable survival in subglottic cancer. Sex remained an independent prognostic factor for both DSS and OS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Sex is an independent prognostic factor for DSS and OS in patients with laryngeal SCC.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.25897","type":"journal-article","created":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T05:18:17Z","timestamp":1565241497000},"page":"3764-3774","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Treatment modality and outcomes in larynx cancer patients: A sex\u2010based evaluation"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0458-0714","authenticated-orcid":false,"given":"Hong","family":"Li","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Yale School of Medicine  New Haven Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8249-4694","authenticated-orcid":false,"given":"Eva Yujia","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Educational Psychology, University of Connecticut  Storrs Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7678-3051","authenticated-orcid":false,"given":"Alexandra Eva","family":"Kejner","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology University of Kentucky  Lexington Kentucky"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,8,7]]},"reference":[{"key":"e_1_2_5_2_1","unstructured":"Laryngeal and Hypopharyngeal Cancer \u2010 Statistics. 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