{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T16:06:11Z","timestamp":1787846771120,"version":"build-2784847793"},"reference-count":33,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,8,22]],"date-time":"2019-08-22T00:00:00Z","timestamp":1566432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The study was aimed to evaluate the impact of accumulated oral tegafur\u2010uracil (UFUR) as maintenance chemotherapy on overall survival (OS) and disease\u2010free survival (DFS) rates after concurrent chemoradiotherapy (CCRT) for complete remission (CR) in non\u2010distant metastatic TNM stage IV nasopharyngeal carcinoma (NPC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were retrospectively analyzed from a database of patients with non\u2010distant metastatic TNM stage IV NPC, composed of those who underwent CCRT for CR from January 2010 through December 2017.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010three patients were treated with CCRT (the non\u2010UFUR group), and the other 37 patients were treated with the same regimen, followed by additional oral UFUR (the UFUR group). Importantly, the 5\u2010year OS rates were 91.89% in the UFUR group and 57.58% in the non\u2010UFUR group (<jats:italic>P<\/jats:italic> = .004).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Adding UFUR to CCRT was found to significantly improve the DFS and OS rates of patients with non\u2010distant metastatic TNM stage IV NPC. The authors cautiously suggest UFUR as possible maintenance therapy following CCRT.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.25904","type":"journal-article","created":{"date-parts":[[2019,8,22]],"date-time":"2019-08-22T07:20:00Z","timestamp":1566458400000},"page":"3775-3782","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Evaluation of oral tegafur\u2010uracil as metronomic therapy following concurrent chemoradiotherapy in patients with non\u2010distant metastatic TNM stage IV nasopharyngeal carcinoma"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6770-1598","authenticated-orcid":false,"given":"Jia\u2010Hong","family":"Chen","sequence":"first","affiliation":[{"name":"Division of Hematology\/Oncology, Department of Medicine Tri\u2010Service General Hospital, National Defense Medical Center  Taipei Taiwan"},{"name":"Graduate Institute of Clinical Medicine, College of Medicine Taipei Medical University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Yen","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Tri\u2010Service General Hospital National Defense Medical Center  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching\u2010Liang","family":"Ho","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, Department of Medicine Tri\u2010Service General Hospital, National Defense Medical Center  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsu\u2010Yi","family":"Chao","sequence":"additional","affiliation":[{"name":"Graduate Institute of Clinical Medicine, College of Medicine Taipei Medical University  Taipei Taiwan"},{"name":"Division of Hematology and Oncology, Department of Medicine Taipei Medical University, Shuang Ho Hospital  New Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jih\u2010Chin","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Tri\u2010Service General Hospital, National Defense Medical Center  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,8,22]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-06-0353"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21262"},{"key":"e_1_2_10_4_1","unstructured":"Nasopharyngeal cancer: statistics. 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