{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T21:50:14Z","timestamp":1772574614559,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,8,30]],"date-time":"2019-08-30T00:00:00Z","timestamp":1567123200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We investigated the impact of level I lymph node involvement (LNI) on survival for patients with oropharyngeal squamous cell carcinoma (OPSCC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a cohort study of patients with OPSCC who underwent resection with known human papillomavirus (HPV) status in the National Cancer Database (2010\u20102014).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 5591 patients with OPSCC, 599 (10.7%) had level I LNI. Predictors of level I LNI included pT classification (pT3 vs pT1; odds ratio [OR], 1.95; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), pN classification (pN3 vs pN1; OR, 1.63; <jats:italic>P<\/jats:italic> = 0.05), and level III LNI (OR, 6.05; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Among included patients, 4035 had known survival status. Level I LNI predicted inferior overall survival (OS) while adjusting for covariates (HR, 1.64; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Subset analyses revealed association between level I LNI and inferior OS among patients with base of tongue cancer, pT\/pN classification greater than 1, and HPV\u2010negative cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Level I LNI predicts inferior OS, particular among patients with at least pT2 or pN2 OPSCC.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.25927","type":"journal-article","created":{"date-parts":[[2019,8,30]],"date-time":"2019-08-30T07:38:17Z","timestamp":1567150697000},"page":"3895-3905","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The prognostic impact of level I lymph node involvement in oropharyngeal squamous cell carcinoma"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4459-0746","authenticated-orcid":false,"given":"Roy","family":"Xiao","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Harvard Medical School  Boston Massachusetts"},{"name":"Department of Otolaryngology Massachusetts Eye and Ear  Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew C.","family":"Ward","sequence":"additional","affiliation":[{"name":"Southeast Radiation Oncology Group  Charlotte North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kailin","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Taussig Cancer Institute, Cleveland Clinic  Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Adelstein","sequence":"additional","affiliation":[{"name":"Department of Hematology and Medical Oncology Taussig Cancer Institute, Cleveland Clinic  Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shlomo A.","family":"Koyfman","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Taussig Cancer Institute, Cleveland Clinic  Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brandon L.","family":"Prendes","sequence":"additional","affiliation":[{"name":"Head and Neck Institute, Cleveland Clinic  Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian B.","family":"Burkey","sequence":"additional","affiliation":[{"name":"Head and Neck Institute, Cleveland Clinic  Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,8,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dji289"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.38.4099"},{"issue":"11","key":"e_1_2_8_4_1","first-page":"3282","article-title":"Smoking and drinking in relation to oral and pharyngeal cancer","volume":"48","author":"Blot WJ","year":"1988","journal-title":"Cancer Res"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.14.1713"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.36.4596"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(05)80554-9"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016480500504259"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000217543.40027.1d"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.10315"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(199701)19:1<14::AID-HED3>3.0.CO;2-Y"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/0284186X.2013.858825"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2008.10.018"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2014.06.008"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28831"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-007-9747-3"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(92)90133-8"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.20.9288"},{"key":"e_1_2_8_19_1","unstructured":"R Core Team.R: A Language and Environment for Statistical Computing. 2017."},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21389"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2006.02.034"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24009"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.129.7.729"}],"container-title":["Head &amp; 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