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Two examiners independently assessed eligibility and risk of bias and extracted data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was improvement in 75.6% of the 41 patients submitted to HBO, with positive effects on pain relief and decreased size and number of lesions at a faster rate, with better effects when the drug was discontinued. For LIL, 158 (64.2%) of the 246 patients\/sites improved the symptoms and 98 (39.8%) healed completely. Fourteen (17.3%) of the 81 patients treated with PRP significantly improved the symptoms and 65 (80.2%) completely healed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These therapies served as safe and effective adjuvant modalities for MRONJ treatment. The lack of randomized clinical trials evidences the need for more high\u2010quality investigations on the subject.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.25944","type":"journal-article","created":{"date-parts":[[2019,9,10]],"date-time":"2019-09-10T09:54:40Z","timestamp":1568109280000},"page":"4209-4228","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Adjuvant therapies in the management of medication\u2010related osteonecrosis of the jaws: Systematic review"],"prefix":"10.1002","volume":"41","author":[{"given":"Elen","family":"de Souza Tolentino","sequence":"first","affiliation":[{"name":"Department of Dentistry State University of Maring\u00e1  Maring\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0394-9647","authenticated-orcid":false,"given":"Tamara F.","family":"de Castro","sequence":"additional","affiliation":[{"name":"Oral Oncology Center S\u00e3o Paulo State University (Unesp), School of Dentistry, Ara\u00e7atuba, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe C.","family":"Michellon","sequence":"additional","affiliation":[{"name":"Department of Dentistry State University of Maring\u00e1  Maring\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana C. 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