{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T03:33:55Z","timestamp":1777433635280,"version":"3.51.4"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,11,13]],"date-time":"2019-11-13T00:00:00Z","timestamp":1573603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008903","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["HI15C1524"],"award-info":[{"award-number":["HI15C1524"]}],"id":[{"id":"10.13039\/100008903","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004085","name":"Ministry of Education, Science and Technology","doi-asserted-by":"publisher","award":["NRF\u20102016R1A2B4010407"],"award-info":[{"award-number":["NRF\u20102016R1A2B4010407"]}],"id":[{"id":"10.13039\/501100004085","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of study is to investigate the role of transient receptor potential cation channel subfamily V member 1 (TRPV1) on xerostomia\u2010induced inflammatory response in vivo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Parotid, submandibular, and lingual gland were removed for xerostomia induction. The expression of inflammatory cytokines, TRPV1, NFkB, and MAPK in xerostomia was evaluated and compared in both TRPV1 wild and knockout mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The level of interleukin\u20106 (IL\u20106) and IL\u201017, neutrophil\/CD4 T\u2010cell infiltration, phosphorylation of extracellular signal\u2010regulated kinase (ERK) and c\u2010Jun N terminal kinase, TRPV1, and the localization of NFkB were elevated in xerostomia\u2010induced TRPV1 wild\u2010type mice. In contrast, inflammatory cytokines and MAPK were decreased in xerostomia\u2010induced TRPV1 knockout mice. TRPV1 antagonist treatment also reduced tongue ulceration, neutrophil\/CD4<jats:sup>+<\/jats:sup> T\u2010cell expression, IL\u20106, and IL\u201017 in TRPV1 wild\u2010type mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>TRPV1 had a crucial role in modulating inflammation in xerostomia and targeting TRPV1 might be a promising therapeutic strategy for xerostomia.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.25980","type":"journal-article","created":{"date-parts":[[2019,11,13]],"date-time":"2019-11-13T09:10:02Z","timestamp":1573636202000},"page":"198-209","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["TRPV1 regulates inflammatory process in the tongue of surgically induced xerostomia mouse"],"prefix":"10.1002","volume":"42","author":[{"given":"Min H.","family":"Yoo","sequence":"first","affiliation":[{"name":"Department of Innovative Toxicology Research Korea Institute of Toxicology  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