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Despite the existence of multiple publications, meaningful information is still lacking in clinical practice and the literature about the ideal method, material, and timing for repair of CSF. The purpose of this review was to summarize the success rate of endoscopic CSF leak repair as well as whether specific techniques or materials influence the primary success rate through a review of the latest advancements in endoscopic CSF management published in the past 10\u2009years. The principles of multilayer reconstructions and the routine use of vascularized flaps in expanded endonasal surgery have reduced postoperative CSF leaks' failure rates between 5% and 10% (4% in this meta\u2010analysis). Effective endoscopic anterior skull base (ASB) closure may be achieved by multiple reconstructive techniques, which should be tailored case by case according to the patient and defect conditions.<\/jats:p>","DOI":"10.1002\/hed.25981","type":"journal-article","created":{"date-parts":[[2019,11,4]],"date-time":"2019-11-04T13:40:12Z","timestamp":1572874812000},"page":"344-356","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The surgical treatment of cerebrospinal fistula: Qualitative and quantitative analysis of indications and results"],"prefix":"10.1002","volume":"42","author":[{"given":"Alessandra","family":"Iavarone","sequence":"first","affiliation":[{"name":"Unit of Otorhinolaryngology Head and Neck Surgery, Department of Surgery and Translational Medicine University of Florence  Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1856-9372","authenticated-orcid":false,"given":"Paolo","family":"Luparello","sequence":"additional","affiliation":[{"name":"Unit of Otorhinolaryngology Head and Neck Surgery, Department of Surgery and Translational Medicine University of Florence  Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Silvia","family":"Lazio","sequence":"additional","affiliation":[{"name":"Unit of Otorhinolaryngology Head and Neck Surgery, Department of Surgery and Translational Medicine University of Florence  Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3639-1504","authenticated-orcid":false,"given":"Lara Valentina","family":"Comini","sequence":"additional","affiliation":[{"name":"Unit of Otorhinolaryngology Head and Neck Surgery, Department of Surgery and Translational Medicine University of Florence  Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Martelli","sequence":"additional","affiliation":[{"name":"Unit of Otorhinolaryngology Head and Neck Surgery, Department of Surgery and Translational Medicine University of Florence  Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliviero","family":"De Luca","sequence":"additional","affiliation":[{"name":"Head and Neck and Robotic Surgery, Department of Experimental and Clinical Medicine University of Florence  Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni Paolo","family":"Santoro","sequence":"additional","affiliation":[{"name":"Head and Neck and Robotic Surgery, Department of Experimental and Clinical Medicine University of Florence  Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Santoro","sequence":"additional","affiliation":[{"name":"Head and Neck and Robotic Surgery, Department of Experimental and Clinical Medicine University of Florence  Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giammarco","family":"Alderotti","sequence":"additional","affiliation":[{"name":"Department of Statistics Science University \u201cLa Sapienza\u201d of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7079-3964","authenticated-orcid":false,"given":"Giuditta","family":"Mannelli","sequence":"additional","affiliation":[{"name":"Head and Neck and Robotic Surgery, Department of Experimental and Clinical Medicine University of Florence  Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,11,4]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2008.12.060"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016484809129635"},{"issue":"3","key":"e_1_2_11_4_1","first-page":"576","article-title":"Iatrogenic cerebrospinal rhinorrhea. 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