{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T18:35:12Z","timestamp":1786386912892,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,10,24]],"date-time":"2019-10-24T00:00:00Z","timestamp":1571875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100010804","name":"Faculty of Medicine, Prince of Songkla University","doi-asserted-by":"publisher","award":["REC 57\u2010073\u201013\u20101"],"award-info":[{"award-number":["REC 57\u2010073\u201013\u20101"]}],"id":[{"id":"10.13039\/501100010804","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Eicosapentaenoic acid (EPA) containing nutritional supplement can reverse weight loss and increase lean body mass in a perioperative period of patients with head and neck cancer. To study effects of an EPA\u2010enriched supplement compared with a conventional supplement in malnourished patients with head and neck cancer following surgery is primary objective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The patients were randomized into EPA\u2010enriched and standard formula group. The supplements were prescribed 7\u2009days preoperative through 14\u2009days postoperative. Body weight and composition including serum parameters were measured from 7\u2009days preoperative until 4 months postoperative. The hospitalized courses were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010one patients in each group consumed EPA\u2010enriched and standard formula supplements. There was no significant body weight or composition changes perioperative. No significant differences in the hospitalized days and postoperative complications was observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Body weight changes in malnourished patients with head and neck cancer following surgery were not influenced by EPA additives to perioperative nutritional supplements.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.25987","type":"journal-article","created":{"date-parts":[[2019,10,24]],"date-time":"2019-10-24T16:40:41Z","timestamp":1571935241000},"page":"188-197","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Efficacy of EPA\u2010enriched supplement compared with standard formula on body weight changes in malnourished patients with head and neck cancer undergone surgery: a randomized study"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8985-814X","authenticated-orcid":false,"given":"Kitti","family":"Jantharapattana","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Faculty of Medicine Prince of Songkla University  Songkhla Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orachat","family":"Orapipatpong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,10,24]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198803000-00008"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-8140(96)01776-8"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8140(02)00404-8"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(199710)19:7<567::AID-HED2>3.0.CO;2-5"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20447"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607188012002195"},{"key":"e_1_2_5_8_1","first-page":"57","article-title":"Prevalence of malnutrition in general surgical patients","volume":"41","author":"Aoun JP","year":"1993","journal-title":"J Med Liban"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/73.2.323"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(199708)19:5<419::AID-HED9>3.0.CO;2-2"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/47.2.352"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198807000-00001"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(87)90028-6"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.167.3.1211"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/014860719201600603"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/379739a0"},{"key":"e_1_2_5_17_1","first-page":"1369","article-title":"Expression of proinflammatory and proangiogenic cytokines in patients with head and neck cancer","volume":"5","author":"Chen Z","year":"1999","journal-title":"Clin Cancer Res"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20246"},{"key":"e_1_2_5_19_1","first-page":"2761","article-title":"Serum levels of interleukin\u20106 in patients with primary head and neck squamous cell carcinoma","volume":"25","author":"Riedel F","year":"2005","journal-title":"Anticancer Res"},{"key":"e_1_2_5_20_1","first-page":"195","article-title":"Surgical nutrition: a review","volume":"38","author":"Saunders C","year":"1993","journal-title":"J R Coll Surg Edinb"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198902023200501"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0899-9007(95)00078-X"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(91)90016-X"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/63.1.116"},{"key":"e_1_2_5_25_1","first-page":"131","article-title":"Catabolic factors in cancer cachexia","volume":"10","author":"Tisdale MJ","year":"1996","journal-title":"In Vivo"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1042\/cs0920215"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.52.10.1479"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1207\/S15327914NC402_7"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e31819a4789"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21580"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.33587"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2010.494336"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41199-018-0033-9"}],"container-title":["Head &amp; 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