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The combination of minimally invasive transoral surgery (TOS) with ICG\u2010SNNS can provide functional preservation options for both primary lesions and lymph node (LN) metastasis. This multicenter feasibility study of this strategy was conducted in Japan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with clinical T1 or T2, N0 oropharyngeal, hypopharyngeal, or supraglottic cancer were enrolled. The identification rate of sentinel nodes, delayed cervical LN metastasis in 2\u2009years, and survival rate were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010two patients (10 oropharynx, 8 hypopharynx, 4 supraglottic cancer) were enrolled. The identification rate was 100%. One case had delayed nodal metastasis. The accuracy was 95.5%, sensitivity was 75%, and specificity was 100%. The 5\u2010year disease\u2010specific survival was 100%, overall survival was 72.3%, and disease\u2010free survival was 60.5%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The combination of TOS with ICG\u2010SNNS is feasible as a minimally invasive strategy and has favorable oncological outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.25993","type":"journal-article","created":{"date-parts":[[2019,10,31]],"date-time":"2019-10-31T14:37:00Z","timestamp":1572532620000},"page":"254-261","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Minimally invasive surgery for laryngopharyngeal cancer: Multicenter feasibility study of a combination strategy involving transoral surgery and real\u2010time indocyanine green fluorescence\u2010navigated sentinel node navigation 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