{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T01:37:42Z","timestamp":1776908262087,"version":"3.51.2"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,11,4]],"date-time":"2019-11-04T00:00:00Z","timestamp":1572825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We investigated whether the pattern of intensity\u2010modulated radiotherapy (IMRT) dose distribution to the skin can be correlated with the development of G3\/G4 radiation dermatitis (RD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A frequency\u2010matched cohort analysis was perfomed on patients treated with IMRT and concurrent cisplatin or cetuximab. Risk ratios were obtained by fitting Poisson regression models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The incidence of G3\/G4 RD was 41.1% in 90 patients included (50% vs 36.6% in the cetuximab and cisplatin cohorts, respectively). In multivariate analysis, PS\u2009\u2265\u20091 and weight loss at RT completion &gt;10 kg were the only factors that retained significance. The best dosimetric predictive accuracy was provided by 19.9 cc and 5.8 cc of skin ring 2\u2009mm\u2009V50 and V60, respectively (AUC: 0.61 for both).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Along with clinical factors, the pattern of dose distribution to a ring structure localized 2\u2009mm below the patient's surface may help predict the development of severe RD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.25997","type":"journal-article","created":{"date-parts":[[2019,11,4]],"date-time":"2019-11-04T13:43:56Z","timestamp":1572875036000},"page":"244-253","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Analysis of skin dose distribution for the prediction of severe radiation dermatitis in head and neck squamous cell carcinoma patients treated with concurrent chemo\u2010radiotherapy"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8999-5208","authenticated-orcid":false,"given":"Pierluigi","family":"Bonomo","sequence":"first","affiliation":[{"name":"Radiation Oncology Azienda Ospedaliero\u2010Universitaria Careggi  Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cinzia","family":"Talamonti","sequence":"additional","affiliation":[{"name":"Medical Physics Azienda Ospedaliero\u2010Universitaria Careggi  Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isacco","family":"Desideri","sequence":"additional","affiliation":[{"name":"Radiation Oncology Azienda Ospedaliero\u2010Universitaria Careggi  Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Livia","family":"Marrazzo","sequence":"additional","affiliation":[{"name":"Medical Physics Azienda Ospedaliero\u2010Universitaria Careggi  Florence 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