{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T01:51:51Z","timestamp":1783389111639,"version":"3.54.6"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,11,15]],"date-time":"2019-11-15T00:00:00Z","timestamp":1573776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2016\/02713\u20102"],"award-info":[{"award-number":["2016\/02713\u20102"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2016\/11419\u20100"],"award-info":[{"award-number":["2016\/11419\u20100"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2018\/12734\u20102"],"award-info":[{"award-number":["2018\/12734\u20102"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>SMARCB1 (INI\u20101)\u2010deficient carcinomas and NUT carcinomas are aggressive neoplasms, often affecting the sinonasal region. Not uncommonly, their diagnoses are made retrospectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Through SMARCB1 (INI\u20101) and NUT immunomarkers, 643 head and neck carcinomas were assessed retrospectively. Moreover, SMARCB1 (INI\u20101)\u2010deficient and NUT carcinomas were additionally evaluated by immunohistochemistry, as well as in situ hybridization analysis for HPV and EBV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Four SMARCB1 (INI\u20101)\u2010deficient carcinomas (located in lower lip, soft palate, hypopharynx and vocal cord, this latter high\u2010risk HPV positive) and three NUT carcinomas (all located in oropharynx) were detected, previously diagnosed as nonkeratinizing or moderately differentiated squamous cell carcinoma. All cases showed squamous differentiation. NUT carcinomas than SMARCB1 (INI\u20101)\u2010deficient carcinomas showed low overall survival rate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The current cases expand the clinicopathological spectrum of SMARCB1 (INI\u20101)\u2010deficient carcinomas and NUT carcinomas. Notably, the diagnosis of these cases is easily reached through immunohistochemistry, with impact on their accurate classification, treatment, and prognosis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.26008","type":"journal-article","created":{"date-parts":[[2019,11,15]],"date-time":"2019-11-15T09:27:19Z","timestamp":1573810039000},"page":"374-384","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["SMARCB1 (INI\u20101) and NUT immunoexpression in a large series of head and neck carcinomas in a Brazilian reference center"],"prefix":"10.1002","volume":"42","author":[{"given":"Rodrigo","family":"Neves\u2010Silva","sequence":"first","affiliation":[{"name":"Oral Pathology, Department of Stomatology, Public Oral Health, and Forensic Dentistry, Ribeir\u00e3o Preto Dental School (FORP\/USP) University of S\u00e3o Paulo  Ribeir\u00e3o Preto S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5403-4052","authenticated-orcid":false,"given":"Luciana Y.","family":"Almeida","sequence":"additional","affiliation":[{"name":"Oral Medicine, Department of Diagnosis and Surgery, Araraquara Dental School S\u00e3o Paulo State University (UNESP)  Araraquara S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6724-3504","authenticated-orcid":false,"given":"Heitor A.","family":"Silveira","sequence":"additional","affiliation":[{"name":"Oral Pathology, Department of Stomatology, Public Oral Health, and Forensic Dentistry, Ribeir\u00e3o Preto Dental School (FORP\/USP) University of S\u00e3o Paulo  Ribeir\u00e3o Preto S\u00e3o Paulo Brazil"},{"name":"Oral Medicine, Department of Diagnosis and Surgery, Araraquara Dental School S\u00e3o Paulo State University (UNESP)  Araraquara S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla B. N.","family":"Colturato","sequence":"additional","affiliation":[{"name":"Oral Pathology, Department of Stomatology, Public Oral Health, and Forensic Dentistry, Ribeir\u00e3o Preto Dental School (FORP\/USP) University of S\u00e3o Paulo  Ribeir\u00e3o Preto S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andressa","family":"Duarte","sequence":"additional","affiliation":[{"name":"Department of Pathology and Forensic Medicine, Ribeir\u00e3o Preto Medical School (FMRP\/USP) University of S\u00e3o Paulo  Ribeir\u00e3o Preto S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9933-2819","authenticated-orcid":false,"given":"Tulio M.","family":"Ferrisse","sequence":"additional","affiliation":[{"name":"Oral Medicine, Department of Diagnosis and Surgery, Araraquara Dental School S\u00e3o Paulo State University (UNESP)  Araraquara S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9883-9776","authenticated-orcid":false,"given":"Ev\u00e2nio V.","family":"Silva","sequence":"additional","affiliation":[{"name":"Oral Medicine, Department of Diagnosis and Surgery, Araraquara Dental School S\u00e3o Paulo State University (UNESP)  Araraquara S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e1rbara F.","family":"Vanzolin","sequence":"additional","affiliation":[{"name":"Oral Pathology, Department of Stomatology, Public Oral Health, and Forensic Dentistry, Ribeir\u00e3o Preto Dental School (FORP\/USP) University of S\u00e3o Paulo  Ribeir\u00e3o Preto S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6714-6253","authenticated-orcid":false,"given":"Andreia","family":"Bufalino","sequence":"additional","affiliation":[{"name":"Oral Medicine, Department of Diagnosis and Surgery, Araraquara Dental School S\u00e3o Paulo State University (UNESP)  Araraquara S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3579-5048","authenticated-orcid":false,"given":"Alfredo","family":"Ribeiro\u2010Silva","sequence":"additional","affiliation":[{"name":"Department of Pathology and Forensic Medicine, Ribeir\u00e3o Preto Medical School (FMRP\/USP) University of S\u00e3o Paulo  Ribeir\u00e3o Preto S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9668-5870","authenticated-orcid":false,"given":"Jorge E.","family":"Le\u00f3n","sequence":"additional","affiliation":[{"name":"Oral Pathology, Department of Stomatology, Public Oral Health, and Forensic Dentistry, Ribeir\u00e3o Preto Dental School (FORP\/USP) University of S\u00e3o Paulo  Ribeir\u00e3o Preto S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000236"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000797"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000285"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2018.08.008"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-015-1853-1"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-019-01065-7"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2019.04.015"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/pin.12720"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-018-4321-x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000173"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S173056"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/pin.12727"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2019.02.012"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.21932"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/1746-1596-8-211"},{"key":"e_1_2_6_17_1","first-page":"348","volume-title":"WHO Classification of Head and Neck Tumours","author":"El\u2010naggar AK","year":"2017"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2015.04.001"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2013.08.029"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-88441-7"},{"key":"e_1_2_6_21_1","first-page":"4362162","article-title":"Squamous cell carcinoma originating from adult laryngeal papillomatosis: case report and review of the literature","volume":"19","author":"Ribeiro El\u2010Achkar VN","year":"2018","journal-title":"Case Rep Otolaryngol"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2010.02.013"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31823f2f17"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23772"},{"key":"e_1_2_6_25_1","first-page":"20","volume-title":"WHO Classification of Head and Neck Tumours","author":"French CA","year":"2017"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001021"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-017-0809-y"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-017-0858-2"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.13143"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-12-1153"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2014.07.006"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2019.01.043"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2014.09.031"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1177\/1066896912451651"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2019.06.012"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-013-0428-1"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.26008","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hed.26008","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.26008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T01:45:46Z","timestamp":1694137546000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.26008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,15]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["10.1002\/hed.26008"],"URL":"https:\/\/doi.org\/10.1002\/hed.26008","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,15]]},"assertion":[{"value":"2019-06-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}