{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T06:17:19Z","timestamp":1773037039505,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,11,28]],"date-time":"2019-11-28T00:00:00Z","timestamp":1574899200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Risk of contralateral nodal metastases in oropharyngeal squamous cell carcinoma (OPSCC) is currently based on clinical risk factors. We propose lymphatic mapping with single photon emission computed tomography (SPECT\u2010CT) for tumor\u2010specific delineation of lymphatic drainage to guide treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective review of lymphatic drainage patterns in cT1\u20102 OPSCC and contralateral cN0 neck with a nonoperative, awake injection of 99\u2009m\u2010Tc sulfur colloid and SPECT\u2010CT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ten patients were reviewed. Primary sites included tonsil (n = 8, 80%) and tongue base (n = 2, 20%). All patients tolerated awake injections with no complications. Nine patients (90%) demonstrated satisfactory migration of radiotracer to neck node(s) with seven (78%) to the ipsilateral lateral neck, one (11%) to the ipsilateral lateral neck and retropharynx, and one (11%) to bilateral lateral neck nodes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Characterization of lymphatic drainage in OPSCC is feasible using a nonoperative injection technique and SPECT\u2010CT. Drainage to the contralateral neck is rare, warranting further study to tailor treatment appropriately.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.26011","type":"journal-article","created":{"date-parts":[[2019,11,28]],"date-time":"2019-11-28T11:55:15Z","timestamp":1574942115000},"page":"385-393","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Lymphatic mapping with SPECT\u2010CT for evaluation of contralateral drainage in lateralized oropharyngeal cancers using an awake injection technique"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0765-5731","authenticated-orcid":false,"given":"Carissa M.","family":"Thomas","sequence":"first","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery, Princess Margaret Cancer Centre University Health Network, University of Toronto  Toronto Ontario Canada"},{"name":"Department of Surgical Oncology, Princess Margaret 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