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Subgroup comparisons based on expander locations and planes were conducted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 7058 patients were included. Tissue expansion was associated with an overall complication rate of 8.73% (616\/7058). The most common complications were extrusion (207\/7009; 3.0%) and hematoma (200\/7009; 2.9%). Overall complications were highest in the scalp (65\/238; 27.3%) and lowest in the mastoid (347\/5688; 6.1%). Complications were more common with expansion in the non\u2010subcutaneous plane (63\/590; 10.7%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In the absence of large clinical trials, systematic reviews such as these can help inform clinical guidelines and provide practitioners with an evidence\u2010based reference to improve informed consent.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.26017","type":"journal-article","created":{"date-parts":[[2019,11,27]],"date-time":"2019-11-27T09:10:25Z","timestamp":1574845825000},"page":"747-762","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Complications of tissue expansion in the head and neck"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8286-6697","authenticated-orcid":false,"given":"Jayson L.","family":"Azzi","sequence":"first","affiliation":[{"name":"Faculty of Medicine University of Ottawa  Ottawa 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