{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T18:12:25Z","timestamp":1778350345081,"version":"3.51.4"},"reference-count":14,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,11,27]],"date-time":"2019-11-27T00:00:00Z","timestamp":1574812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Oropharyngeal squamous cell carcinomas (OPSCC) can occur in either tonsillar related areas (TRA) or nontonsillar areas (nTRA). The prognostic differences between these sites are unclear. This study investigated this question using the National Cancer Database (NCDB), controlling for other confounders including human papillomavirus (HPV) status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This NCDB study was conducted by stratifying the HPV\u2010positive oropharyngeal cancer cohort into two primary groups, TRA and nTRA. Kaplan Meier survival analysis was stratified according to HPV status, and further analysis was conducted using multivariable Cox regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 23\u2009297 patients were included in this study. In the multivariable cox regression analysis, OPSCC subsite was found to be an independent prognostic factor for survival (TRA vs nTRA HR: 0.76, 95% CI: 0.67\u20100.86,\n                      <jats:italic>P<\/jats:italic>\n                      &lt;\u2009.0001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this large cohort, OPSCC subsite was found to be an independent prognostic factor for survival.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.26019","type":"journal-article","created":{"date-parts":[[2019,11,27]],"date-time":"2019-11-27T04:18:34Z","timestamp":1574828314000},"page":"434-445","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Anatomical subsite modifies survival in oropharyngeal squamous cell carcinoma: National Cancer Database study"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5928-762X","authenticated-orcid":false,"given":"Tristan","family":"Tham","sequence":"first","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery Zucker School of Medicine at Hofstra\/Northwell  New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seungjun","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Feinstein Institute of Medical Research  Manhasset New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas","family":"Frank","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery Zucker School of Medicine at Hofstra\/Northwell  New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis","family":"Kraus","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery Zucker School of Medicine at Hofstra\/Northwell  New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Costantino","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery Zucker School of Medicine at Hofstra\/Northwell  New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,11,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21388"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.25778"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.13140"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semdp.2015.02.023"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2019.05.006"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-015-4525-0"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-007-9747-3"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)70471-1"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pvr.2017.05.002"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.31820"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2016.02.011"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24774"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1916-0216-43-2"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.27130"}],"container-title":["Head &amp; 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