{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T21:32:35Z","timestamp":1778880755779,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,11,27]],"date-time":"2019-11-27T00:00:00Z","timestamp":1574812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To report our institution's experience treating soft palate squamous cell carcinoma with radiotherapy alone or combined with adjuvant chemotherapy and\/or neck dissection for residual disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed 159 patients treated curatively between 1963 and 2016. Median follow\u2010up was 4\u2009years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The 5\u2010year local control rates were T1, 90%; T2, 90%; T3, 70%; and T4, 59%. The 5\u2010year cause\u2010specific survival (CSS) rate was nearly identical for patients with stage I\u2010III disease (88%, 86%, and 88%, respectively) compared to stage IVA\/B (58%). Five\u2010year overall survival was similar between patients with stage I\u2010III disease (50%, 57%, and 54%, respectively) and approximately double that of patients with stage IVA\/B disease (26%). Thirteen patients (8%) had severe complications related to radiotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The likelihood of cure after definitive radiotherapy is relatively high in patients with stage I\u2010III disease with soft palate carcinoma. Patients with stage IVA\/B disease have a lower cure rate but with a 5\u2010year CSS exceeding 50%.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.26035","type":"journal-article","created":{"date-parts":[[2019,11,27]],"date-time":"2019-11-27T09:14:18Z","timestamp":1574846058000},"page":"530-538","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Radiation treatment of soft palate squamous cell carcinoma"],"prefix":"10.1002","volume":"42","author":[{"given":"Cooper T.","family":"Rapp","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology University of Florida  Gainesville Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhishamjit S.","family":"Chera","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of North Carolina  Chapel Hill North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher G.","family":"Morris","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Florida  Gainesville Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9850-0964","authenticated-orcid":false,"given":"Robert J.","family":"Amdur","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Florida  Gainesville Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica M.","family":"Kirwan","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Florida  Gainesville Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6592-2810","authenticated-orcid":false,"given":"William M.","family":"Mendenhall","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Florida  Gainesville Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,11,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2013.12.019"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.36.4596"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)70471-1"},{"key":"e_1_2_7_5_1","first-page":"41","volume-title":"AJCC Cancer Staging Manual","author":"American Joint Committee on Cancer","year":"2015"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21146"},{"key":"e_1_2_7_7_1","unstructured":"Centers for Disease Control and Prevention. 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