{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:29:49Z","timestamp":1787027389180,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,12,18]],"date-time":"2019-12-18T00:00:00Z","timestamp":1576627200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Although slow growing, head and neck paragangliomas (HNPG) can cause significant morbidity. We evaluated the efficacy of proton therapy in the management of HNPG.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective review of an institutional proton therapy experience of treating patients between 1997 and 2016; 37 patients and 40 tumors were included.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Proton therapy was delivered to a median of 50.4\u2009Gy(RBE) (range: 45\u201068). Having a genetic\/family predisposition for HNPG was associated with multifocal tumors (\n                      <jats:italic>P\u2009=<\/jats:italic>\n                      .02) and younger diagnosis age (\n                      <jats:italic>P\u2009=<\/jats:italic>\n                      .02). Twenty\u2010six (70%) patients had symptom improvement posttreatment, and 65% of treated tumors showed \u226520% volumetric shrinkage. The 5\u2010year recurrence\u2010free and overall survival rates were both 97%. Grade 2 to grade 3 toxicities (54%) included subjective hearing impairment (19%), middle ear inflammation (14%), and dry mouth (8%). There were no grade 4\u20105 toxicities.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients with HNPGs can be effectively and safely treated with proton therapy with excellent tumor control, successful volumetric tumor reduction, and symptomatic improvement.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.26044","type":"journal-article","created":{"date-parts":[[2019,12,18]],"date-time":"2019-12-18T07:43:17Z","timestamp":1576654997000},"page":"670-677","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Proton therapy for head and neck paragangliomas: A single institutional experience"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4484-3689","authenticated-orcid":false,"given":"Kylie H.","family":"Kang","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Massachusetts General Hospital  Boston Massachusetts"},{"name":"Case Western Reserve University School of Medicine  Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily S.","family":"Lebow","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Massachusetts General Hospital  Boston Massachusetts"},{"name":"Harvard Medical School  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrzej","family":"Niemierko","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Massachusetts General Hospital  Boston Massachusetts"},{"name":"Harvard Medical School  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc R.","family":"Bussi\u00e8re","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Massachusetts General Hospital  Boston Massachusetts"},{"name":"Harvard Medical School  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas A.","family":"Dewyer","sequence":"additional","affiliation":[{"name":"Harvard Medical School  Boston Massachusetts"},{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Massachusetts Eye and Ear Infirmary  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jillian","family":"Daly","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Massachusetts General Hospital  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"McKenna","sequence":"additional","affiliation":[{"name":"Harvard Medical School  Boston Massachusetts"},{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Massachusetts Eye and Ear Infirmary  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Lee","sequence":"additional","affiliation":[{"name":"Harvard Medical School  Boston Massachusetts"},{"name":"Department of Otology and Neurotology Massachusetts Eye and Ear Infirmary  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay S.","family":"Loeffler","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Massachusetts General Hospital  Boston Massachusetts"},{"name":"Harvard Medical School  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul M.","family":"Busse","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Massachusetts General Hospital  Boston Massachusetts"},{"name":"Harvard Medical School  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen 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