{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T17:49:17Z","timestamp":1780076957104,"version":"3.54.0"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,1,10]],"date-time":"2020-01-10T00:00:00Z","timestamp":1578614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sinonasal undifferentiated carcinomas (SNUCs), being an aggressive malignancy with dismal survival outcome, have given limited consideration regarding management of regional failures. A total of 12 studies, published between 1999 and 2019, met inclusion criteria. We performed a meta\u2010analysis assessing regional (neck) relapse after elective neck treatment compared to observation in clinically node negative (N0) necks. Clinical data of 255 patients were used for meta\u2010analysis. Among them, 83.4% of patients presented with T4 tumors and 14.1% had positive neck nodes. Elective neck treatment was applied in 49.5% of analyzed patients. Regional relapses occurred in 3.7% of patients who have undergone elective neck treatment compared to 26.4% in patients who had not. Elective neck treatment significantly reduced the risk of regional recurrence (odds ratio 0.20; 95% confidence interval 0.08\u20100.49; <jats:italic>P<\/jats:italic> =\u2009.0004). The meta\u2010analysis indicates that elective neck treatment could significantly reduce the risk of regional failures in patients with SNUCs.<\/jats:p>","DOI":"10.1002\/hed.26077","type":"journal-article","created":{"date-parts":[[2020,1,10]],"date-time":"2020-01-10T10:09:54Z","timestamp":1578650994000},"page":"1057-1066","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Elective neck treatment in sinonasal undifferentiated carcinoma: Systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6564-0410","authenticated-orcid":false,"given":"Muhammad","family":"Faisal","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Institute of Head and Neck Diseases, Evangelical Hospital Vienna  Vienna Austria"},{"name":"Department of Head and Neck Surgery Shaukat Khanum Memorial Cancer Hospital and Research Centre  Lahore 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