{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T16:09:19Z","timestamp":1762272559119,"version":"3.40.5"},"reference-count":45,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,2,14]],"date-time":"2020-02-14T00:00:00Z","timestamp":1581638400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Wisconsin Head & Neck Cancer SPORE","award":["P50DE026787"],"award-info":[{"award-number":["P50DE026787"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To evaluate disease control, toxicities, and dose to dysphagia\/aspiration risk structures (DARS) using a direct gross tumor volume (GTV<jats:sub>70Gy<\/jats:sub>) to planning target volume expansion (dPTV<jats:sub>70Gy<\/jats:sub>) for patients with squamous cell carcinoma of the larynx (LSCC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective review was performed on patients with LSCC treated between 2003 and 2018. Clinical outcomes, toxicities, and dosimetric data were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy\u2010three patients were identified. Overall survival at 5\u2010years was 57.8%. Five\u2010year local and regional control was 79.8% and 88.2%, respectively. Distant metastatic\u2010only failure was 2.7%. Eighty percent of failures were 95% contained within the dPTV<jats:sub>70Gy<\/jats:sub>. Mean dose and the volume of DARS receiving 70\u2009Gy was significantly lower for dPTV<jats:sub>70Gy<\/jats:sub> compared to a consensus\u2010defined PTV<jats:sub>70Gy<\/jats:sub>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Judicious reduction in high\u2010dose target volumes can preserve high tumor control rates while reducing dose to normal surrounding structures underscoring the potential benefit of this approach in enabling local therapy intensification to improve locoregional control.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.26098","type":"journal-article","created":{"date-parts":[[2020,2,14]],"date-time":"2020-02-14T13:10:09Z","timestamp":1581685809000},"page":"1874-1881","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Clinical outcomes for larynx patients with cancer treated with refinement of high\u2010dose radiation treatment 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