{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T08:44:06Z","timestamp":1792226646478,"version":"4.4.0"},"reference-count":40,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,3,18]],"date-time":"2020-03-18T00:00:00Z","timestamp":1584489600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Treating recurrent pleomorphic adenoma (RPA) aims to reduce risk of malignant transformation (MT) while avoiding facial nerve injury. Our objective was to systematically investigate this natural history of RPA and address the current rational for its treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The follow\u2010up data of two nationwide series of PA was pooled with a focus on risk of MT and analyzed against the literature.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The combined nationwide data (n = 9003 PA patients) showed 3.1% with first recurrence of which 6.2% were malignant. In the literature first RPA rate was &gt;7% at 20\u2009years follow\u2010up. MT occurred in 0% to 7%, and facial nerve damage increased from with each surgery 3% to 16% at first RPA to 18% to 30% at second RPA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>RPA showed a characteristic course with surgery being unreliable and damage to the facial nerve. The risk of MT was low. This might give flexibility towards a more conservative approach of management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.26137","type":"journal-article","created":{"date-parts":[[2020,3,18]],"date-time":"2020-03-18T17:22:26Z","timestamp":1584552146000},"page":"2058-2066","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Natural history of recurrent pleomorphic adenoma: implications on management"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2415-0893","authenticated-orcid":false,"given":"Matthijs H.","family":"Valstar","sequence":"first","affiliation":[{"name":"Department of Head and Neck Oncology and Surgery Netherlands Cancer Institute  Amsterdam the Netherlands"},{"name":"Department of Oral\u2010Maxillofacial Surgery, Amsterdam UMC University of Amsterdam  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Andreasen","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery and Audiology Rigshospitalet, Copenhagen University Hospital  Copenhagen Denmark"},{"name":"Department of Otorhinolaryngology and Maxillofacial Surgery Zealand University Hospital  K\u00f8ge Denmark"},{"name":"Department of Pathology Rigshospitalet, Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick A.","family":"Bhairosing","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Oncology and Surgery Netherlands Cancer Institute  Amsterdam the Netherlands"},{"name":"Scientific Information Service, Netherlands Cancer Institute  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2822-639X","authenticated-orcid":false,"given":"Mark","family":"McGurk","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery University College Hospitals  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24228"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2017.01.004"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1986.03780110056007"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(89)90501-4"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2880120410"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(96)00293-0"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-197802000-00008"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2006.06.036"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100123667"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348949510400203"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000637-199806000-00001"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02630721"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20613"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0266-4356(98)90748-3"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.1036"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199110000-00006"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.MLG.0000166697.48868.8C"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.2310\/7070.2004.03022"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-010-1173-2"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2004.11.008"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-007-0502-y"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(99)70053-7"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.3342\/ceo.2009.2.4.193"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-016-3921-9"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215113001801"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2005.04.008"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.24392"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599814528098"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800831227"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0000000000000435"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800751129"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01607152"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2011.03758.x"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000001237"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2014.02.026"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.23396"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.2307\/3579909"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-018-5205-z"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24964"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003489417708794"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.26137","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.26137","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hed.26137","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.26137","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T19:22:06Z","timestamp":1693941726000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.26137"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,18]]},"references-count":40,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["10.1002\/hed.26137"],"URL":"https:\/\/doi.org\/10.1002\/hed.26137","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.737584881.793580018","asserted-by":"object"}]},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,18]]},"assertion":[{"value":"2019-08-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}