{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T14:06:35Z","timestamp":1775138795558,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,7,16]],"date-time":"2020-07-16T00:00:00Z","timestamp":1594857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The role of induction chemotherapy (IC) in locally\u2010advanced head and neck squamous cell carcinoma (LAHNSCC) is unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective study of 104 patients with LAHNSCC of the larynx and hypopharynx, treated with IC or up\u2010front chemoradiotherapy (CRT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighty patients received CRT and 24 IC followed by CRT; median follow up was 51.33\u2009months. IC significantly improved median overall survival (OS) in the hypopharyngeal cancer group (64.7 vs 21\u2009months, <jats:italic>P<\/jats:italic> = .003); with significant difference in the proportion of complete response at first imaging assessment post definitive CRT; no significant difference in disease free survival (DFS), loco\u2010regional or distant failure in the hypopharyngeal cancer group; or OS and DFS in the laryngeal cancer group. Patients with laryngeal cancer had significantly better median OS than those with hypopharyngeal cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>IC significantly improved complete response rates after CRT, and improved outcomes for patients with locally advanced hypopharyngeal, not laryngeal, cancers.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.26353","type":"journal-article","created":{"date-parts":[[2020,7,16]],"date-time":"2020-07-16T07:58:20Z","timestamp":1594886300000},"page":"3118-3124","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Induction chemotherapy for locally advanced laryngeal and hypopharyngeal cancer: Single institution experience"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2425-5414","authenticated-orcid":false,"given":"Or","family":"Dagan","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery, Affiliated with Rappaport Faculty of Medicine, The Technion  Hadera Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1502-3729","authenticated-orcid":false,"given":"Assaf","family":"Moore","sequence":"additional","affiliation":[{"name":"Institute of Oncology, Davidoff Cancer Center Rabin Medical Center\u2014Beilinson Hospital  Petach Tikva Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6202-4647","authenticated-orcid":false,"given":"Yuval","family":"Nachalon","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel Aviv University  Tel Aviv Israel"},{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery Rabin Medical Center\u2014Beilinson Hospital  Petach Tikva 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